Abstract—We studied the content of brain-derived neurotrophic factor (BDNF) and ciliary neurotrophic factor (CNTF) in serum and lacrimal fluid in 105 patients with depression (unipolar depression, 37 and bipolar depression, 68). The stimulated lacrimal fluid was taken from one randomly selected eye with a pipette dispenser. The concentrations of BDNF and CNTF were determined by enzyme-linked immunosorbent assay. We observed a decrease in the concentration of BDNF in the blood serum of patients (22 380 ± 3600 pg/mL) compared to healthy controls (25 220 ± 3550 pg/mL). The concentration of CNTF in patients was increased both in blood serum (6.7 ± 2.8 compared with 4.4 ± 2.3 pg/mL) and in lacrimal fluid (35.8 ± 9.8 vs 31.0 ± 5.3 pg/mL). CNTF values in blood serum and in the lacrimal fluid weakly correlated with each other. The increase in the level of CNTF in lacrimal fluid of patients with depression indirectly indicates an increase in CNTF in the aqueous humor of the anterior chamber of the eye, and possibly in the cerebrospinal fluid, which, requires further study.

中文翻译：

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抑郁症患者的脑源性神经营养因子和睫状神经营养因子

摘要—我们研究了105例抑郁症患者（单极性抑郁症37和双极性抑郁症68）的血清和泪液中脑源性神经营养因子（BDNF）和睫状神经营养因子（CNTF）的含量。用移液器从随机选择的一只眼睛中取出刺激的泪液。通过酶联免疫吸附测定法测定BDNF和CNTF的浓度。我们观察到与健康对照组（25 220±3550 pg / mL）相比，患者血清中BDNF浓度降低（22 380±3600 pg / mL）。患者血清中CNTF的浓度（6.7±2.8与4.4±2.3 pg / mL相比）和泪液中（35.8±9.8 vs 31.0±5.3 pg / mL）均增加。血清和泪液中的CNTF值之间的相关性很弱。