Abstract—Serotonin receptors of subtype 1А (5-HT1A) are involved in the regulation of aggressive behavior. New data show that 5-HT1A receptors are capable of heterodimerization and antagonistic interaction with type 7 serotonin receptors (5-HT7); hence, it is important to study the involvement of 5-НТ7 receptors in aggressive behavior. Specifically, it is necessary to study the patterns of co-expression of 5-НТ1А and 5-НТ7 receptors in the brains of animals that differ in the degree of genetically defined aggression. In this paper, we have studied the expression of serotonin 5-НТ1А and 5-НТ7 receptors in several cerebral structures of rats with genetically defined aggressive behavior or the lack of aggression. We have revealed significant changes in the expression of these receptors both at mRNA and receptor protein levels. Of particular interest is the changes in the levels of the membrane protein of 5-НТ1А and 5-НТ7 receptors in the midbrain and hippocampus of aggressive rats. A decrease in the level of 5-НТ1А receptors in the midbrain is associated with an increase in the level of this receptor in the hippocampus; meanwhile, the level of 5-НТ7 receptor is increased in the midbrain and decreased in the hippocampus of aggressive rats compared to tame animals. These data indicate interaction between 5-НТ7 and 5-НТ1А receptors. In addition, the expression of 5‑НТ7 receptors is increased in the frontal cortex and the mRNA level of the 5-НТ7 receptor gene is decreased in the hypothalamus of aggressive rats compared to tame animals. Therefore, significant changes in the expression of 5-НТ7 receptors in the brain of rats selected for a high level of fear-induced aggression towards humans have been revealed for the first time. Genotype-dependent peculiarities of combined expression of 5-НТ1А and 5-НТ7 receptors have been revealed in the investigated brain structures. Our data suggest that interaction between 5-НТ1А- and 5-НТ7-receptors may be an important factor in the regulation of genetically defined aggression.

中文翻译：

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遗传确定的恐惧诱发的攻击行为或缺乏攻击的大鼠脑内5-羟色胺受体1А和7的表达模式

摘要-1А亚型（5-HT1A）血清素受体参与攻击行为的调节。新数据表明5-HT1A受体能够与7型5-羟色胺受体（5-HT7）异源二聚化和拮抗相互作用。因此，研究5-НТ7受体参与攻击行为很重要。具体来说，有必要研究在动物的大脑中5НТ1А和5НТ7受体在基因定义的攻击程度上不同的共表达模式。在本文中，我们研究了5-羟色胺5-НТ1А和5-НТ7受体在具有遗传定义的攻击行为或缺乏攻击性的大鼠的几种大脑结构中的表达。我们已经揭示了这些受体在mRNA和受体蛋白水平上的表达均发生了显着变化。特别令人感兴趣的是攻击性大鼠中脑和海马中5-НТ1А和5-НТ7受体的膜蛋白水平的变化。中脑中5-НТ1А受体水平的降低与海马中该受体水平的升高有关。同时，与驯服动物相比，攻击性大鼠中脑中5-НТ7受体的水平升高，海马中的5-НТ7受体水平降低。这些数据表明5-НТ7和5-НТ1А受体之间的相互作用。此外，与驯化动物相比，攻击性大鼠的下丘脑中前额皮层5‑НТ7受体的表达增加，而5-НТ7受体基因的mRNA水平降低。因此，首次揭示了选择用于高水平恐惧引起的对人类侵略的大鼠脑中5-НТ7受体表达的显着变化。在研究的大脑结构中发现了5-НТ1А和5-НТ7受体联合表达的基因型依赖性。我们的数据表明，5-НТ1А-和5-НТ7受体之间的相互作用可能是调节遗传定义的攻击的重要因素。