Transient receptor potential vanilloid 4 (TRPV4) is a nonselective Ca²⁺-permeable cation channel that is a member of the TRP channel family. It is clear that TRPV4 channels are broadly expressed in the brain. As they are expressed on the plasma membrane, they interact with other channels and play a crucial role in nervous system activity. Under some pathological conditions, TRPV4 channels are upregulated and sensitized via cellular signaling pathways, and this can cause nervous system diseases. In this review, we focus on receptors that cooperate with TRPV4, including large-conductance Ca²⁺-activated K⁺(BKca) channels, N-methyl-D-aspartate receptors (NMDARs), α-amino-3-hydroxy-5-methyl-4-isoxazole-propionate receptors (AMPARs), inositol 1,4,5-trisphosphate receptors (IP3Rs), ryanodine receptors (RyRs), aquaporin 4 (AQP4), and other potential cooperative receptors in the brain. The data demonstrate how these channels work together to cause nervous system diseases under pathological conditions. The aim of this review was to discuss the receptors and signaling pathways related to TRPV4 based on recent data on the important physiological functions of TRPV4 channels to provide new clues for future studies and prospective therapeutic targets for related brain diseases.

瞬时受体电位香草醛 4 (TRPV4) 是一种非选择性的 Ca ²⁺渗透性阳离子通道，是 TRP 通道家族的成员。很明显，TRPV4 通道在大脑中广泛表达。由于它们在质膜上表达，它们与其他通道相互作用并在神经系统活动中发挥关键作用。在某些病理条件下，TRPV4通道通过细胞信号通路上调和致敏，从而导致神经系统疾病。在这篇综述中，我们关注与 TRPV4 合作的受体，包括大电导 Ca ²⁺激活的 K ⁺ (BKca) 通道、N-甲基-D-天冬氨酸受体 (NMDAR)、α-氨基-3-羟基-5-甲基-4-异恶唑丙酸酯受体 (AMPAR)、肌醇 1,4,5-三磷酸受体 (IP3Rs)、兰尼碱受体 (RyRs )、水通道蛋白 4 (AQP4) 和大脑中其他潜在的协同受体。数据证明了这些通道如何在病理条件下共同作用导致神经系统疾病。本综述旨在根据近期有关TRPV4通道重要生理功能的数据，探讨TRPV4相关的受体和信号通路，为相关脑疾病的未来研究和前瞻性治疗靶点提供新线索。