Despite the distinction between ischemic stroke and neurodegenerative disorders, they share numerous pathophysiologies particularly those mediated by inflammation and oxidative stress. Although protein aggregation is considered to be a hallmark of neurodegenerative diseases, the formation of protein aggregates can be also induced within a short time after cerebral ischemia, aggravating cerebral ischemic injury. Protein aggregation uncovers a previously unappreciated molecular overlap between neurodegenerative diseases and ischemic stroke. Unfortunately, compared with neurodegenerative disease, mechanism of protein aggregation after cerebral ischemia and how this can be averted remain unclear. This review highlights current understanding on protein aggregation and its intrinsic role in ischemic stroke.

尽管缺血性中风和神经退行性疾病之间存在区别，但它们共享许多病理生理学，特别是由炎症和氧化应激介导的病理生理学。虽然蛋白质聚集被认为是神经退行性疾病的标志，但在脑缺血后短时间内也可诱导蛋白质聚集形成，加重脑缺血损伤。蛋白质聚集揭示了神经退行性疾病和缺血性中风之间以前未被重视的分子重叠。不幸的是，与神经退行性疾病相比，脑缺血后蛋白质聚集的机制以及如何避免这种情况仍不清楚。本综述强调了当前对蛋白质聚集及其在缺血性卒中中的内在作用的理解。