Toxicity from drugs has become an important cause of acute liver failure. Acetaminophen, a commonly used analgesic, can cause severe acute liver injury that can worsen into acute liver failure. Autophagy, a protective cell programme, has been reported to have protective effects in a variety of diseases such as cancer, immune diseases, neurodegenerative diseases, and inflammatory diseases. In this review, we describe how an excess of acetaminophen causes liver injury step by step, from the formation of the initial protein adduct to the final hepatocyte necrosis, as well as the induction of autophagy and its beneficial effects on diseases. Emphasis is placed on the potential effect of autophagy on improving the damage of acetaminophen to hepatocytes. Finally, we are committed to providing insights into the treatment of acute liver failure through the mechanism of acetaminophen induced liver injury, the mechanism of autophagy, and the link between autophagy and liver injury.

药物毒性已经成为急性肝衰竭的重要原因。对乙酰氨基酚，一种常用的镇痛药，可引起严重的急性肝损伤，并可能恶化为急性肝衰竭。自噬是一种保护性细胞程序，据报道对多种疾病如癌症，免疫性疾病，神经退行性疾病和炎性疾病具有保护作用。在这篇综述中，我们描述了过量的对乙酰氨基酚如何逐步地引起肝损伤，从最初的蛋白质加合物的形成到最终的肝细胞坏死，以及自噬的诱导及其对疾病的有益作用。重点放在自噬在改善对乙酰氨基酚对肝细胞的损害方面的潜在作用。最后，