Background Diffusion-weighted imaging (DWI) is an imaging modality using multi-section single-shot spin echo planar imaging (EPI) sequence which is extremely sensitive for detection of water motion within intra, extra, and transcellular regions. This character is important to differentiate between brain tumors either low (benign) or highly (malignant) cellular tumors. Objective To evaluate the role of DWI and apparent diffusion coefficient (ADC) in evaluation and differentiation between different brain posterior fossa tumors in children and adults. Patients and methods The study included 34 patients with different brain posterior fossa tumors for evaluation by conventional MRI (using 1.5 T MRI PHILIPS Achieva 2.1 Best Netherland) and DWI. Results Our study showed that mean ADC values were significantly different between the four groups of posterior fossa tumors in children: juvenile pilocytic astrocytoma (JPA), medulloblastoma, ependymoma, and brain stem glioma while mean ADC values were not significantly different between posterior fossa tumors in the adult group. Regions of interest were manually positioned, and all values were automatically calculated and expressed in 10 −3 mm 2 /s. Conclusion DWI is an ideal additional imaging technique, which is a rapid, easy, non-invasive imaging modality, with no contrast injection needed. It has been widely applied in the differentiation between posterior fossa brain tumors and in the diagnosis of various intracranial diseases.

中文翻译：

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弥散加权成像在区分后颅窝脑肿瘤中的作用

背景 扩散加权成像 (DWI) 是一种使用多节单次自旋回波平面成像 (EPI) 序列的成像方式，它对于检测细胞内、细胞外和跨细胞区域内的水运动非常敏感。该特征对于区分低度（良性）或高度（恶性）细胞肿瘤的脑肿瘤很重要。目的评价DWI和表观扩散系数（ADC）在儿童和成人不同脑后颅窝肿瘤的评估和鉴别中的作用。患者和方法 该研究包括 34 名患有不同脑后颅窝肿瘤的患者，以通过常规 MRI（使用 1.5 T MRI PHILIPS Achieva 2.1 Best Netherland）和 DWI 进行评估。结果 我们的研究表明，4 组儿童后颅窝肿瘤的平均 ADC 值有显着差异：幼年毛细胞星形细胞瘤 (JPA)、成神经管细胞瘤、室管膜瘤和脑干胶质瘤，而平均 ADC 值在儿童后颅窝肿瘤之间没有显着差异。成人组。感兴趣的区域被手动定位，并且所有值都被自动计算并以10 -3 mm 2 /s 表示。结论 DWI 是一种理想的附加成像技术，它是一种快速、简便、无创的成像方式，无需注射造影剂。它已广泛应用于后颅窝脑肿瘤的鉴别和各种颅内疾病的诊断。和脑干胶质瘤，而成人组后颅窝肿瘤的平均 ADC 值没有显着差异。感兴趣的区域被手动定位，并且所有值都被自动计算并以10 -3 mm 2 /s 表示。结论 DWI 是一种理想的附加成像技术，它是一种快速、简便、无创的成像方式，无需注射造影剂。它已广泛应用于后颅窝脑肿瘤的鉴别和各种颅内疾病的诊断。和脑干胶质瘤，而成人组后颅窝肿瘤的平均 ADC 值没有显着差异。感兴趣的区域被手动定位，并且所有值都被自动计算并以10 -3 mm 2 /s 表示。结论 DWI 是一种理想的附加成像技术，它是一种快速、简便、无创的成像方式，无需注射造影剂。它已广泛应用于后颅窝脑肿瘤的鉴别和各种颅内疾病的诊断。非侵入性成像方式，无需注射造影剂。它已广泛应用于后颅窝脑肿瘤的鉴别和各种颅内疾病的诊断。非侵入性成像方式，无需注射造影剂。它已广泛应用于后颅窝脑肿瘤的鉴别和各种颅内疾病的诊断。