Background Epilepsy is a neurological disorder characterized by convulsions. Identification of biological pathways underlying epilepsy and novel genes may shed light on the pathogenesis of epilepsy as well as new targets for treatment. Objectives Amylin is cosecreted with insulin from the pancreatic β-cells in a pulsatile manner as a response to nutrient stimuli. In vitro studies have shown the neurotoxicity potential of amylin. We aimed to investigate serum amylin levels between epilepsy patients and a healthy control group. Subjects and methods For this study, 45 patients with epilepsy and 60 healthy controls were enrolled. Routine blood analysis and electroencephalography scan were performed for all participants. Five cc venous blood sample was collected from each participant. Sera were isolated and stored at − 80 °C until the time of amylin analysis with the enzyme-linked immunosorbent assay. Results Gender distribution of the two groups was as follows: 44.4% males and 55.6% females among epileptic patients and 53.3% males and 46.7% females for control subjects. Body mass index was 23.09 ± 3.99 kg/m 2 for epileptic patients and 26.29 ± 4.83 kg/m 2 for controls, with a statistically significantly higher body mass index in control subjects ( p ˂ 0.001). With regard to serum amylin levels, a statistically significant difference was observed between the two groups ( p ˂ 0.001). The median serum amylin concentration was 226.62 ng/ml (69.49–6961.19 (min–max)) for epileptic patients and 103.66 ng/ml (37.42–607.11 (min–max)) for controls ( p ˂ 0.001). Conclusion In the present study, a significant difference was observed between patient and control groups in serum amylin concentrations, which were considerably higher in epileptic patients.

中文翻译：

---

血清胰淀素水平与癫痫的关系

背景癫痫是一种以抽搐为特征的神经系统疾病。癫痫潜在生物学途径和新基因的鉴定可能有助于阐明癫痫的发病机制以及新的治疗靶点。目的 胰岛淀粉样多肽与胰岛 β 细胞中的胰岛素以脉动方式共分泌，作为对营养刺激的反应。体外研究表明胰淀素具有潜在的神经毒性。我们旨在调查癫痫患者和健康对照组之间的血清胰淀素水平。受试者和方法 在这项研究中，招募了 45 名癫痫患者和 60 名健康对照者。对所有参与者进行了常规血液分析和脑电图扫描。从每位参与者收集 5 毫升静脉血样本。血清被分离并储存在 - 80°C，直到用酶联免疫吸附测定法分析胰淀素。结果两组性别分布如下：癫痫患者男性44.4%，女性55.6%，对照组男性53.3%，女性46.7%。癫痫患者的体重指数为 23.09 ± 3.99 kg/m 2 ，对照组为 26.29 ± 4.83 kg/m 2 ，对照组受试者的体重指数在统计学上显着更高 (p ˂ 0.001)。在血清胰淀素水平方面，两组之间观察到统计学上的显着差异（p˂0.001）。癫痫患者的中位血清胰淀素浓度为 226.62 ng/ml (69.49-6961.19 (min-max))，对照组为 103.66 ng/ml (37.42-607.11 (min-max)) (p ˂ 0.001)。结论 在本研究中，