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Neutrophil–lymphocyte ratio and response to plasmapheresis in Guillain–Barré syndrome: a prospective observational study
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Pub Date : 2020-01-30 , DOI: 10.1186/s41983-020-0154-z
Noha Ali Hashim , Wafaa Samir Mohamed , Engy Mohammed Emad

Background Guillain–Barré Syndrome (GBS) is one of the most severe neurological diseases that causes marked disability and even death. Aim The aim of this study is to investigate the role of the neutrophil–lymphocyte ratio (NLR) as a prognostic marker for GBS and response to treatment with plasmapheresis. Methods Seventy-five subjects (35 GBS patients and 40 healthy controls) were recruited. Complete general and neurological examinations were performed and Hughes disability scale score was evaluated for assessing functional motor deficits in GBS patients. In addition, NLR, erythrocyte sedimentation rate, and C-reactive protein level were calculated. Results NLR was significantly higher in GBS patients than in controls ( p < 0.001) and was significantly higher in axonal form than other demyelinating and mixed subtypes ( p < 0.02). Patients with a poor outcome had a significantly high NLR than patients with a good outcome ( p = 0.006). NLR was also positively correlated with Hughes disability scale score ( p < 0.001). The cut-off value for NLR to predict a good response of patients to plasmapheresis was ≤ 4.4. Interpretation NLR may be a rapid, simple, inexpensive biomarker for predicting the severity of GBS, outcome of patients, and their response to plasmapheresis.

中文翻译:

格林-巴利综合征中性粒细胞-淋巴细胞比率和血浆置换反应:一项前瞻性观察研究

背景 格林-巴利综合征 (GBS) 是最严重的神经系统疾病之一,会导致明显的残疾甚至死亡。目的 本研究的目的是研究中性粒细胞-淋巴细胞比率 (NLR) 作为 GBS 预后标志物和血浆置换治疗反应的作用。方法 75 名受试者(35 名 GBS 患者和 40 名健康对照者)被招募。进行了全面的全身检查和神经系统检查,并评估了休斯残疾量表评分以评估 GBS 患者的功能性运动缺陷。此外,还计算了 NLR、红细胞沉降率和 C 反应蛋白水平。结果 GBS 患者的 NLR 显着高于对照组( p < 0.001),轴突形式的 NLR 显着高于其他脱髓鞘和混合亚型( p < 0.02)。结果较差的患者的 NLR 显着高于结果良好的患者 (p = 0.006)。NLR 也与休斯残疾量表评分呈正相关(p < 0.001)。NLR 预测患者对血浆置换的良好反应的临界值≤ 4.4。解释 NLR 可能是一种快速、简单、廉价的生物标志物,用于预测 GBS 的严重程度、患者的结果以及他们对血浆置换的反应。
更新日期:2020-01-30
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