The main mechanism of acute coronary syndrome (ACS) is the rupture of atherosclerotic plaques. Matrix metalloproteinases (MMPs) play an important role in the rupture of the vulnerable plaques. MMP secretion is stimulated by CD147, one of the immunoglobulin families. Malondialdehyde is an important marker of oxidative damage, which is related to the atherosclerotic process. Superoxide dismutase normally prevents the oxidative process. This study was conducted to evaluate the association of ACS with CD147 gene expression, lipid peroxidation, and antioxidants in Egyptian population. The study included 124 people, 62 ACS patients and 62 healthy controls. CD147 gene expression in the ACS group was significantly increased compared to the control group (p < 0.001). The ACS was 9.71 ± 3.56-fold; the control group was 0.94 ± 0.19-fold. Also, the SOD activity in the ACS group was significantly increased when compared to the control group (t = 16.023, p < 0.001). There was a highly significant increase in the MDA level in ACS groups when compared to the control group (t = 35.536, p < 0.001). There was a highly significant increase in the creatine kinase-MB (CK-MB) and high sensitive troponin I levels in ACS groups when compared to the control group (p < 0.001). There is a highly significant positive correlation between CK-MB and CD147 in both control and ACS groups (p = <0.001**); also, there is highly significant positive correlation between high sensitive troponin I and CD 147 in both control and ACS groups (p = <0.001**), but we did not find significant correlation between SOD and CD147 or between MDA and CD 147 in both control and ACS groups.

中文翻译：

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CD147基因表达、脂质过氧化和抗氧化剂在埃及人群急性冠脉综合征病例中的评价

急性冠状动脉综合征（ACS）的主要机制是动脉粥样硬化斑块的破裂。基质金属蛋白酶 (MMPs) 在易损斑块的破裂中起重要作用。MMP 分泌受到 CD147（免疫球蛋白家族之一）的刺激。丙二醛是氧化损伤的重要标志物，与动脉粥样硬化过程有关。超氧化物歧化酶通常会阻止氧化过程。本研究旨在评估埃及人群中 ACS 与 CD147 基因表达、脂质过氧化和抗氧化剂的关联。该研究包括 124 人、62 名 ACS 患者和 62 名健康对照者。与对照组相比，ACS 组的 CD147 基因表达显着增加（p < 0.001）。ACS 为 9.71 ± 3.56 倍；对照组为 0.94 ± 0.19 倍。还，与对照组相比，ACS 组的 SOD 活性显着增加（t = 16.023，p < 0.001）。与对照组相比，ACS 组的 MDA 水平显着增加（t = 35.536，p < 0.001）。与对照组相比，ACS 组的肌酸激酶-MB (CK-MB) 和高敏感肌钙蛋白 I 水平显着增加（p < 0.001）。在对照组和 ACS 组中，CK-MB 和 CD147 之间存在高度显着的正相关（p = <0.001**）；此外，在对照组和 ACS 组中，高敏肌钙蛋白 I 和 CD 147 之间存在高度显着的正相关（p = <0.001**），但我们没有发现 SOD 和 CD147 或 MDA 和 CD 147 之间的显着相关性控制组和 ACS 组。