Diabetic is one of the fundamental persuasive of diabetic nephropathy and significantly sparks off kidney diseases and end stage renal failure globally. The current research was carried out to evaluate hypoglycemic potential and nephroprotective effect of ethanolic extract of Mikania scandens leaves by using alloxan-induced diabetic nephropathy (DN) mice. The mice were intraperitoneally treated with (200 mg/kg) Mikania scandens leaves extract and standard (120 mg/kg) metformin HCL solution up to 22 days. During this treatment period, we collected blood for evaluation of different types of parameters such as blood glucose level body weight at 0, 15, 22th days, serum creatinine, uric acid, total protein were estimated at the end of the experiment (day 22). Mikania scandens leaves extract significantly (p < 0.05) lessen blood glucose level, serum creatinine, total protein and uric acid. Apart this, cytotoxicity studies were assessed by Brine Shrimp Lethality Bioassay. By this method, we measure the dose of LC50. The plant has high LC50 dose thus cytotoxicity has ensued at massive amount and safe to administer. Lowering of serum creatinine, uric acid and total protein recommend that the ethanolic extract of Mikania scandens possess potent nephroprotective activity and assure the traditional avail of this plant in the management of diabetes nephropathy.

中文翻译：

---

用四氧嘧啶诱导的糖尿病肾病小鼠评估薇甘菊叶子乙醇提取物的肾保护和细胞毒性作用

糖尿病是糖尿病性肾病的基本说服力之一，在全球范围内可明显引发肾脏疾病和晚期肾衰竭。目前的研究是通过使用四氧嘧啶诱导的糖尿病肾病（DN）小鼠来评估薇甘菊scan叶乙醇提取物的降血糖潜力和对肾脏的保护作用。用（200 mg / kg）薇甘菊叶子提取物和标准（120 mg / kg）二甲双胍HCL溶液腹膜内处理小鼠长达22天。在此治疗期间，我们收集了血液以评估不同类型的参数，例如在第0、15、22天时的血糖水平体重，在实验结束时（第22天）估算了血清肌酐，尿酸和总蛋白。薇甘菊scan叶提取物可显着降低（p <0.05）血糖水平，血清肌酐，总蛋白和尿酸。除此之外，通过盐水虾致死率生物测定法评估了细胞毒性研究。通过这种方法，我们测量了LC50的剂量。该植物具有高LC50剂量，因此产生了大量细胞毒性并且可以安全施用。降低血清肌酐，尿酸和总蛋白含量建议，薇甘菊的乙醇提取物具有强大的肾脏保护活性，可确保该植物在糖尿病肾病治疗中的传统功效。