The cerebellum is a region of the brain that plays an important role in motor control. It is classified phylogenetically into archicerebellum, paleocerebellum and neocerebellum. The Purkinje cells are lined in a row called Purkinje cell layer and it has a unique dendritic branches with many spines. The previous study reported that there is a difference of synapse density according to the lobules based on large two-dimensional data. However, recent study with high voltage electron microscopy showed there was no differences in dendritic spine density of the Purkinje cell according to its phylogenetic lobule. We analyzed Purkinje cell density in the II, VI and X lobules by stereological modules and synaptic density was estimated by double disector based on Purkinje cell density in the molecular layer of each lobule. The results showed that there was significant difference in the Purkinje cell density and synapse number according to their phylogenetic lobules. The number of Purkinje cell in a given volume was larger in the archicerebellum, but synapse density was higher in the neocerebellum. These data suggest that cellular and synaptic organization of the Purkinje cell is different according to their phylogenetic background.

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浦肯野细胞树突棘与大鼠小脑系统发育小叶平行纤维曲张的差异突触密度

小脑是大脑的一个区域，在运动控制中起着重要作用。它在系统发育上分为原始小脑、古小脑和新小脑。浦肯野细胞排列成一排，称为浦肯野细胞层，它有一个独特的树突状分支，有许多刺。之前的研究报告了基于大二维数据的小叶突触密度存在差异。然而，最近的高压电子显微镜研究表明，根据其系统发育小叶，浦肯野细胞的树突棘密度没有差异。我们通过立体模块分析了 II、VI 和 X 小叶中的浦肯野细胞密度，并根据每个小叶分子层中的浦肯野细胞密度通过双解剖器估计了突触密度。结果表明，根据系统发育小叶的不同，浦肯野细胞密度和突触数量存在显着差异。给定体积中浦肯野细胞的数量在大小脑中较大，但在新小脑中突触密度较高。这些数据表明浦肯野细胞的细胞和突触组织根据它们的系统发育背景而不同。