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Platelet Responses in Cardiovascular Disease: Sex-Related Differences in Nutritional and Pharmacological Interventions.
Cardiovascular Therapeutics ( IF 3.1 ) Pub Date : 2020-05-27 , DOI: 10.1155/2020/2342837 Valeria Gasperi 1 , M Valeria Catani 1 , Isabella Savini 1
Cardiovascular Therapeutics ( IF 3.1 ) Pub Date : 2020-05-27 , DOI: 10.1155/2020/2342837 Valeria Gasperi 1 , M Valeria Catani 1 , Isabella Savini 1
Affiliation
Cardiovascular diseases (CVD) represent one of the biggest causes of death globally, and their prevalence, aetiology, and outcome are related to genetic, metabolic, and environmental factors, among which sex- and age-dependent differences may play a key role. Among CVD risk factors, platelet hyperactivity deserves particular mention, as it is involved in the pathophysiology of main cardiovascular events (including stroke, myocardial infarction, and peripheral vascular injury) and is closely related to sex/age differences. Several determinants (e.g., hormonal status and traditional cardiovascular risk factors), together with platelet-related factors (e.g., plasma membrane composition, receptor signaling, and platelet-derived microparticles) can elucidate sex-related disparity in platelet functionality and CVD onset and outcome, especially in relation to efficacy of current primary and secondary interventional strategies. Here, we examined the state of the art concerning sex differences in platelet biology and their relationship with specific cardiovascular events and responses to common antiplatelet therapies. Moreover, as healthy nutrition is widely recognized to play a key role in CVD, we also focused our attention on specific dietary components (especially polyunsaturated fatty acids and flavonoids) and patterns (such as Mediterranean diet), which also emerged to impact platelet functions in a sex-dependent manner. These results highlight that full understanding of gender-related differences will be useful for designing personalized strategies, in order to prevent and/or treat platelet-mediated vascular damage.
中文翻译:
心血管疾病中的血小板反应:营养和药理学干预中的性别相关差异。
心血管疾病(CVD)是全球最大的死亡原因之一,其患病率,病因和结果与遗传,代谢和环境因素有关,其中性别和年龄相关的差异可能起关键作用。在CVD危险因素中,血小板多动症特别值得一提,因为它参与主要心血管事件(包括中风,心肌梗塞和周围血管损伤)的病理生理,并且与性别/年龄差异密切相关。几个决定因素(例如激素状态和传统的心血管危险因素)以及血小板相关因素(例如(质膜组成,受体信号传导和血小板衍生的微粒)可以阐明与血小板相关的性别差异,CVD发作和预后,尤其是与当前主要和次要干预策略的疗效有关。在这里,我们检查了有关血小板生物学中性别差异及其与特定心血管事件的关系以及对常用抗血小板疗法的反应的最新技术水平。此外,由于公认的健康营养在CVD中起关键作用,因此我们也将注意力集中在特定的饮食成分(尤其是多不饱和脂肪酸和类黄酮)和模式(例如地中海饮食)上,这些饮食成分也逐渐影响了CVD的血小板功能。依赖性别的方式。
更新日期:2020-05-27
中文翻译:
心血管疾病中的血小板反应:营养和药理学干预中的性别相关差异。
心血管疾病(CVD)是全球最大的死亡原因之一,其患病率,病因和结果与遗传,代谢和环境因素有关,其中性别和年龄相关的差异可能起关键作用。在CVD危险因素中,血小板多动症特别值得一提,因为它参与主要心血管事件(包括中风,心肌梗塞和周围血管损伤)的病理生理,并且与性别/年龄差异密切相关。几个决定因素(例如激素状态和传统的心血管危险因素)以及血小板相关因素(例如(质膜组成,受体信号传导和血小板衍生的微粒)可以阐明与血小板相关的性别差异,CVD发作和预后,尤其是与当前主要和次要干预策略的疗效有关。在这里,我们检查了有关血小板生物学中性别差异及其与特定心血管事件的关系以及对常用抗血小板疗法的反应的最新技术水平。此外,由于公认的健康营养在CVD中起关键作用,因此我们也将注意力集中在特定的饮食成分(尤其是多不饱和脂肪酸和类黄酮)和模式(例如地中海饮食)上,这些饮食成分也逐渐影响了CVD的血小板功能。依赖性别的方式。