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Functional Glycopolypeptides: Synthesis and Biomedical Applications
Advances in Polymer Technology ( IF 3.1 ) Pub Date : 2020-06-02 , DOI: 10.1155/2020/6052078
Zhao Wang 1 , Xiaojuan Zhang 1 , Qing Lin 1 , Jingjing Sun 2 , Santanu Bhattachaya 3 , Guosong Chen 4 , Ruilong Sheng 5
Affiliation  

Employing natural-based renewable sugar and saccharide resources to construct functional biopolymer mimics is a promising research frontier for green chemistry and sustainable biotechnology. As the mimics/analogues of natural glycoproteins, synthetic glycopolypeptides attracted great attention in the field of biomaterials and nanobiotechnology. This review describes the synthetic strategies and methods of glycopolypeptides and their analogues, the functional self-assemblies of the synthesized glycopolypeptides, and their biological applications such as biomolecular recognition, drug/gene delivery, and cell adhesion and targeting, as well as cell culture and tissue engineering. Future outlook of the synthetic glycopolypeptides was also discussed.

中文翻译:

功能性糖多肽:合成和生物医学应用

利用基于天然的可再生糖和糖类资源构建功能性生物聚合物模拟物是绿色化学和可持续生物技术的一个有前途的研究前沿。作为天然糖蛋白的模拟物/类似物,合成糖多肽在生​​物材料和纳米生物技术领域引起了极大的关注。这篇综述描述了糖多肽及其类似物的合成策略和方法、合成糖多肽的功能自组装及其生物学应用,如生物分子识别、药物/基因递送、细胞粘附和靶向,以及细胞培养和组织工程。还讨论了合成糖多肽的未来前景。
更新日期:2020-06-02
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