With the development of tissue engineering, the required biomaterials need to have the ability to promote cell adhesion and proliferation in vitro and in vivo. Especially, surface modification of the scaffold material has a great influence on biocompatibility and functionality of materials. The small intestine submucosa (SIS) is an extracellular matrix isolated from the submucosal layer of porcine jejunum, which has good tissue mechanical properties and regenerative activity, and is suitable for cell adhesion, proliferation and differentiation. In recent years, SIS is widely used in different areas of tissue reconstruction, such as blood vessels, bone, cartilage, bladder and ureter, etc. This paper discusses the main methods for surface modification of SIS to improve and optimize the performance of SIS bioscaffolds, including functional group bonding, protein adsorption, mineral coating, topography and formatting modification and drug combination. In addition, the reasonable combination of these methods also offers great improvement on SIS surface modification. This article makes a shallow review of the surface modification of SIS and its application in tissue engineering.

中文翻译：

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组织工程中小肠粘膜下层的表面修饰。

随着组织工程学的发展，所需的生物材料必须具有在体外和体内促进细胞粘附和增殖的能力。。特别地，支架材料的表面改性对材料的生物相容性和功能性有很大影响。小肠粘膜下层（SIS）是从猪空肠粘膜下层分离的细胞外基质，具有良好的组织机械性能和再生活性，适合细胞粘附，增殖和分化。近年来，SIS被广泛用于组织重建的不同领域，例如血管，骨骼，软骨，膀胱和输尿管等。本文讨论了SIS表面修饰的主要方法，以改善和优化SIS生物支架的性能。包括官能团键合，蛋白质吸附，矿物涂层，形貌和格式修饰以及药物组合。此外，这些方法的合理组合还可以大大改善SIS表面改性。本文对SIS的表面修饰及其在组织工程中的应用进行了简要回顾。