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Biomimetic and electroactive 3D scaffolds for human neural crest-derived stem cell expansion and osteogenic differentiation
MRS Communications ( IF 1.9 ) Pub Date : 2020-03-01 , DOI: 10.1557/mrc.2020.10
Donata Iandolo , Jonathan Sheard , Galit Karavitas Levy , Charalampos Pitsalidis , Ellasia Tan , Anthony Dennis , Ji-Seon Kim , Athina E. Markaki , Darius Widera , Róisín M. Owens

Osteoporosis is a skeletal disease characterized by bone loss and bone microarchitectural deterioration. The combination of smart materials and stem cells represents a new therapeutic approach. In the present study, highly porous scaffolds are prepared by combining the conducting polymer PEDOT:PSS with collagen type I, the most abundant protein in bone. The inclusion of collagen proves to be an effective way to modulate their mechanical properties and it induces an increase in scaffolds’ electrochemical impedance. The biomimetic scaffolds support neural crest-derived stem cell osteogenic differentiation, with no need for scaffold pre-conditioning contrarily to other reports.

中文翻译:

用于人类神经嵴干细胞扩增和成骨分化的仿生和电活性 3D 支架

骨质疏松症是一种以骨质流失和骨微结构退化为特征的骨骼疾病。智能材料和干细胞的结合代表了一种新的治疗方法。在本研究中,通过将导电聚合物 PEDOT:PSS 与 I 型胶原蛋白(骨骼中含量最高的蛋白质)相结合,制备了高度多孔的支架。加入胶原蛋白被证明是调节其机械性能的有效方法,并且会导致支架电化学阻抗的增加。仿生支架支持神经嵴衍生的干细胞成骨分化,与其他报告相反,不需要支架预处理。
更新日期:2020-03-01
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