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Monolithic quartz platform for cellular contact guidance
MRS Communications ( IF 1.9 ) Pub Date : 2020-03-16 , DOI: 10.1557/mrc.2020.15
Michael C. Robitaille , Joseph A. Christodoulides , Jinny L. Liu , Wonmo Kang , Jeff M. Byers , Katarina Doctor , Dmitry Kozak , Marc P. Raphael

Contact guidance is vital to many physiological processes, yet is still poorly understood. This is partly due to the variability of experimental platforms, making comparisons difficult. To combat this, a multiplexed approach was used to fabricate topographical cues on single quartz coverslips for high-throughput screening. Furthermore, this method offers control of surface roughness and protein adsorption characterization, two critical aspects to the in vitro environment often overlooked in contact guidance platforms. The quartz surface can be regenerated, is compatible with versatile microscopy modes, and can scale up for manufacturing offering a novel platform that could serve as a potential standard assay.



中文翻译:

单片石英平台,用于细胞接触指导

接触指导对于许多生理过程至关重要,但仍知之甚少。部分原因是实验平台的可变性,使比较变得困难。为了解决这个问题,采用了多种方法在单个石英盖玻片上制作形貌线索,以进行高通量筛选。此外,该方法提供了对表面粗糙度和蛋白质吸附特性的控制,这是接触指导平台中经常忽略的体外环境的两个关键方面。石英表面可以再生,与多种显微镜模式兼容,并且可以扩大制造规模,从而提供可以用作潜在标准检测方法的新型平台。

更新日期:2020-03-16
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