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Depression among TB patients and associated factors in Kathmandu Valley, Nepal
Global Mental Health ( IF 3.9 ) Pub Date : 2020-01-22 , DOI: 10.1017/gmh.2019.28 P. Shrestha , U. K. Subba , M. Brouwer , A. C. Sweetland
Global Mental Health ( IF 3.9 ) Pub Date : 2020-01-22 , DOI: 10.1017/gmh.2019.28 P. Shrestha , U. K. Subba , M. Brouwer , A. C. Sweetland
Introduction When tuberculosis (TB) and depression co-occur, there is greater risk for comorbidities, disability, suffering, and health-related costs. Depression is also associated with poor treatment adherence in patients with TB. The major aim of this study was to assess the symptoms of depression and associated factors among TB patients currently receiving directly observed treatment short-course (DOTS) treatment. Methods A cross-sectional study was conducted among TB patients currently undergoing treatment in 27 DOTS centers in three districts of Kathmandu Valley. The study included 250 TB patients within 2 months of treatment initiation, aged 18 years and above. The previously validated Nepali Patient Health Questionnaire (PHQ-9) was used to screen for depression and semi-structured interviews were conducted to collect socio-demographic information and other factors related to TB and/or depression. Data analysis was conducted using IBM SPSS Statistics version 20. Results The study found the mean PHQ Score to be 2.84 (s.d. 4.92, range 0–25). Among the respondents, 10% (n = 25) had PHQ-9 scores ⩾10, suggestive of probable depression. Multivariate linear regression indicated that depressive symptoms were significantly associated with being separated/widowed/divorced (p = 0.000) and having lower education (0.003). In addition, smoking (p = 0.02), alcohol use (p = 0.001), and experience of side effects from TB medications (p = 0.001) were risk factors for higher PHQ-9 scores. Conclusions Our findings suggest that patients on TB treatment have higher risk of depression and efforts should be made by the National Tuberculosis Program to address this issue.
中文翻译:
尼泊尔加德满都谷地结核病患者的抑郁症及相关因素
引言 当结核病 (TB) 和抑郁症同时发生时,合并症、残疾、痛苦和与健康相关的费用的风险更大。抑郁症还与结核病患者的治疗依从性差有关。本研究的主要目的是评估目前接受直接观察短期治疗 (DOTS) 治疗的结核病患者的抑郁症状和相关因素。方法对目前在加德满都谷地三个地区的 27 个 DOTS 中心接受治疗的结核病患者进行横断面研究。该研究包括治疗开始后 2 个月内的 250 名 18 岁及以上的 TB 患者。先前验证的尼泊尔患者健康问卷 (PHQ-9) 用于筛查抑郁症,并进行半结构化访谈以收集与结核病和/或抑郁症相关的社会人口信息和其他因素。使用 IBM SPSS Statistics 20 版进行数据分析。 结果 研究发现平均 PHQ 得分为 2.84(sd 4.92,范围 0-25)。在受访者中,10%(n = 25) PHQ-9 评分 10,提示可能患有抑郁症。多元线性回归表明,抑郁症状与分居/丧偶/离婚显着相关(p = 0.000) 和受教育程度较低 (0.003)。此外,吸烟(p = 0.02), 饮酒 (p = 0.001),以及结核病药物副作用的经历(p = 0.001) 是 PHQ-9 得分较高的风险因素。结论 我们的研究结果表明,接受结核病治疗的患者患抑郁症的风险较高,国家结核病项目应努力解决这一问题。
更新日期:2020-01-22
中文翻译:
尼泊尔加德满都谷地结核病患者的抑郁症及相关因素
引言 当结核病 (TB) 和抑郁症同时发生时,合并症、残疾、痛苦和与健康相关的费用的风险更大。抑郁症还与结核病患者的治疗依从性差有关。本研究的主要目的是评估目前接受直接观察短期治疗 (DOTS) 治疗的结核病患者的抑郁症状和相关因素。方法对目前在加德满都谷地三个地区的 27 个 DOTS 中心接受治疗的结核病患者进行横断面研究。该研究包括治疗开始后 2 个月内的 250 名 18 岁及以上的 TB 患者。先前验证的尼泊尔患者健康问卷 (PHQ-9) 用于筛查抑郁症,并进行半结构化访谈以收集与结核病和/或抑郁症相关的社会人口信息和其他因素。使用 IBM SPSS Statistics 20 版进行数据分析。 结果 研究发现平均 PHQ 得分为 2.84(