A highly efficient disulfide rebridging strategy for the modification of monoclonal antibodies with substituted divinyltriazine linkers is reported. The reaction proceeds efficiently under mild conditions with near stoichiometric quantities of linker. This method of conjugation yields serum stable antibody conjugates with a controlled payload loading of 4.

中文翻译：

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用功能化的二乙烯基三嗪进行高效和选择性的抗体修饰。

报道了用取代的二乙烯基三嗪接头修饰单克隆抗体的高效二硫化物再杂交策略。该反应在温和条件下以接近化学计量的连接子有效地进行。这种缀合方法可产生有效负载为4的血清稳定抗体缀合物。