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Controlled functionalization of carbon nanodots for targeted intracellular production of reactive oxygen species.
Nanoscale Horizons ( IF 9.7 ) Pub Date : 2020-06-10 , DOI: 10.1039/d0nh00300j Ding-Kun Ji 1 , Giacomo Reina , Shi Guo , Matilde Eredia , Paolo Samorì , Cécilia Ménard-Moyon , Alberto Bianco
Nanoscale Horizons ( IF 9.7 ) Pub Date : 2020-06-10 , DOI: 10.1039/d0nh00300j Ding-Kun Ji 1 , Giacomo Reina , Shi Guo , Matilde Eredia , Paolo Samorì , Cécilia Ménard-Moyon , Alberto Bianco
Affiliation
Controlled intracellular release of exogenous reactive oxygen species (ROS) is an innovative and efficient strategy for cancer treatment. Well-designed materials, which can produce ROS in targeted cells, minimizing side effects, still need to be explored as new generation nanomedicines. Here, red-emissive carbon nanodots (CNDs) with intrinsic theranostic properties are devised, and further modified with folic acid (FA) ligand through a controlled covalent functionalization for targeted cell imaging and intracellular production of ROS. We demonstrated that covalent functionalization is an effective strategy to prevent the aggregation of the dots, leading to superior colloidal stability, enhanced luminescence and ROS generation. Indeed, the functional nanodots possess a deep-red emission and good dispersibility under physiological conditions. Importantly, they show excellent targeting properties and generation of high levels of ROS under 660 nm laser irradiation, leading to efficient cell death. These unique properties enable FA-modified carbon nanodots to act as a multifunctional nanoplatform for simultaneous targeted imaging and efficient photodynamic therapy to induce cancer cell death.
中文翻译:
碳纳米点的受控功能化,用于活性氧物质的靶向细胞内生产。
控制性的细胞内释放外源性活性氧(ROS)是一种创新且有效的癌症治疗策略。设计良好的材料可以在目标细胞中产生ROS,从而最大程度地减少副作用,但仍需要探索作为新一代纳米药物。在这里,设计了具有固有治疗论性质的红色发光碳纳米点(CND),并通过叶酸(FA)配体通过受控的共价官能化对其进行了进一步修饰,以用于靶向细胞成像和ROS的细胞内产生。我们证明了共价功能化是防止点聚集的有效策略,可导致优异的胶体稳定性,增强的发光和ROS生成。实际上,功能性纳米点在生理条件下具有深红色发射和良好的分散性。重要的是,它们在660 nm激光辐照下显示出出色的靶向性能和高水平的ROS生成,从而导致有效的细胞死亡。这些独特的特性使FA修饰的碳纳米点能够充当多功能纳米平台,用于同时靶向成像和有效的光动力疗法,以诱导癌细胞死亡。
更新日期:2020-07-27
中文翻译:
碳纳米点的受控功能化,用于活性氧物质的靶向细胞内生产。
控制性的细胞内释放外源性活性氧(ROS)是一种创新且有效的癌症治疗策略。设计良好的材料可以在目标细胞中产生ROS,从而最大程度地减少副作用,但仍需要探索作为新一代纳米药物。在这里,设计了具有固有治疗论性质的红色发光碳纳米点(CND),并通过叶酸(FA)配体通过受控的共价官能化对其进行了进一步修饰,以用于靶向细胞成像和ROS的细胞内产生。我们证明了共价功能化是防止点聚集的有效策略,可导致优异的胶体稳定性,增强的发光和ROS生成。实际上,功能性纳米点在生理条件下具有深红色发射和良好的分散性。重要的是,它们在660 nm激光辐照下显示出出色的靶向性能和高水平的ROS生成,从而导致有效的细胞死亡。这些独特的特性使FA修饰的碳纳米点能够充当多功能纳米平台,用于同时靶向成像和有效的光动力疗法,以诱导癌细胞死亡。