We introduce a multi-step microfluidic reactor for the synthesis of hybrid nanoparticles. As part of this study, nanoparticles composed of chitosan and iron-oxide are synthesized at room temperature by forming sequential droplets of reagents in the microreactor followed by merging and mixing them in a step by step process. The obtained nanoparticles were characterized by transmission electron microscopy (TEM),Fourier transform infrared spectrometry (FTIR), and energy dispersive x-ray analysis(EDX). Results were compared with nanoparticles of same composition synthesized with batch-wise conventional techniques. As a result, the obtained nanoparticles showed better size distribution. This microfluidic device can be used for the synthesis of other types of nanoparticles that require multi-step procedures.

中文翻译：

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用于合成杂化纳米粒子的多步微流体反应器

我们介绍了一种用于合成混合纳米粒子的多步微流体反应器。作为这项研究的一部分，由壳聚糖和氧化铁组成的纳米粒子在室温下合成，方法是在微反应器中形成连续的试剂液滴，然后逐步合并和混合它们。通过透射电子显微镜（TEM）、傅里叶变换红外光谱（FTIR）和能量色散X射线分析（EDX）对所得纳米颗粒进行表征。结果与用分批常规技术合成的相同组成的纳米颗粒进行比较。结果，获得的纳米颗粒显示出更好的尺寸分布。这种微流体装置可用于合成需要多步程序的其他类型的纳米粒子。