In this study, we constructed multifunctional liposomes with preferentially mitochondria-targeted feature and gold nanoparticles-assisted synergistic photodynamic therapy. We systemically investigated the in vitro X-ray triggered PDT effect of these liposomes on HCT 116 cells including the levels of singlet oxygen, mitochondrial membrane potential, cell apoptosis/necrosis and the expression of apoptosis-related proteins. The results corroborated that synchronous action of PDT and X-ray radiation enhance the generation of cytotoxic reactive oxygen species produced from the engineered liposomes, causing mitochondrial dysfunction and increasing the levels of apoptosis.

中文翻译：

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X射线诱导的线粒体靶向脂质体递送系统的光动力疗法（PDT）。

在这项研究中，我们构建了具有优先线粒体靶向特征和金纳米颗粒辅助协同光动力疗法的多功能脂质体。我们系统地研究了这些脂质体对HCT 116细胞的体外X射线触发的PDT效应，包括单线态氧水平，线粒体膜电位，细胞凋亡/坏死和凋亡相关蛋白的表达。该结果证实了PDT和X射线辐射的同步作用增强了工程脂质体产生的细胞毒性活性氧的产生，导致线粒体功能障碍并增加了细胞凋亡水平。