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Supramolecular subphthalocyanine complexes-cellular uptake and phototoxicity.
Chemical Communications ( IF 4.9 ) Pub Date : 2020-06-10 , DOI: 10.1039/d0cc03065a Justin Dubbert 1 , Alexander Höing 2 , Nathalie Riek 1 , Shirley K Knauer 2 , Jens Voskuhl 1
Chemical Communications ( IF 4.9 ) Pub Date : 2020-06-10 , DOI: 10.1039/d0cc03065a Justin Dubbert 1 , Alexander Höing 2 , Nathalie Riek 1 , Shirley K Knauer 2 , Jens Voskuhl 1
Affiliation
In this communication we report on the synthesis and application of axially functionalized boron-subphthalocyanines (SubPC) which are able to form host–guest complexes with cyclodextrins. Here, a tert-butylphenyl substituted SubPC was investigated concerning its complexation with β-cyclodextrin (β-CD) and a β-cyclodextrin polymer. NMR-titrations showed the formation of a 1 : 1 complex with β-CD. These assemblies were analyzed for their cellular distribution as well as their phototoxicity towards HeLa cells.
中文翻译:
超分子亚酞菁复合物-细胞摄取和光毒性。
在本交流中,我们报道了能够与环糊精形成主体-客体复合物的轴向功能化硼-亚酞菁(SubPC)的合成和应用。在此,研究了叔丁基苯基取代的SubPC与β-环糊精(β-CD)和β-环糊精聚合物的络合作用。NMR-滴定表明与β-CD形成1:1络合物。分析了这些组装体的细胞分布以及它们对HeLa细胞的光毒性。
更新日期:2020-07-09
中文翻译:
超分子亚酞菁复合物-细胞摄取和光毒性。
在本交流中,我们报道了能够与环糊精形成主体-客体复合物的轴向功能化硼-亚酞菁(SubPC)的合成和应用。在此,研究了叔丁基苯基取代的SubPC与β-环糊精(β-CD)和β-环糊精聚合物的络合作用。NMR-滴定表明与β-CD形成1:1络合物。分析了这些组装体的细胞分布以及它们对HeLa细胞的光毒性。