Frontotemporal dementia (FTD) is a neurodegenerative syndrome characterized by degenerative changes in behavior, executive function, and/or language that are accompanied by volume loss in frontal and anterior temporal brain regions.¹ Neuropsychiatric symptoms are a prominent feature of this disorder and can include apathy, behavioral disinhibition, loss of empathy, compulsive behaviors, and others.² Overall frequency of formal current or past psychiatric disorder diagnosis is not thought to be increased in patients with FTD³ although this is somewhat controversial.⁴ Regarding depression, a meta-analysis in 2015 exploring the prevalence of depressive symptoms in FTD found that depressed mood is likely elevated in patients compared to healthy age matched controls and as prevalent in FTD as in other dementias including Alzheimer disease, vascular dementia, and dementia with Lewy bodies.⁵ Also, it is known that patients with dementia have a 3 to 10-fold increased risk of death by suicide.⁶ However, there have been few studies examining the prevalence of suicidality in FTD patients specifically.

中文翻译：

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额颞叶痴呆和自杀；遗传学可能是一个关键因素吗？

额颞叶痴呆 (FTD) 是一种神经退行性综合征，其特征是行为、执行功能和/或语言发生退行性变化，并伴有额叶和前颞脑区域的体积减少。¹神经精神症状是这种疾病的一个显着特征，可能包括冷漠、行为去抑制、失去同理心、强迫行为等。^{2在 FTD 3}患者中，正式的当前或过去的精神障碍诊断的总体频率并未增加，尽管这有些争议。^4个关于抑郁症，2015 年一项探索 FTD 抑郁症状患病率的荟萃分析发现，与健康年龄匹配的对照组相比，抑郁情绪在患者中可能升高，并且在 FTD 中与其他痴呆症（包括阿尔茨海默病、血管性痴呆和痴呆症）一样普遍与路易体。⁵此外，众所周知，患有痴呆症的患者自杀死亡的风险会增加 3 到 10 倍。⁶然而，很少有研究专门检查 FTD 患者的自杀率。