Context: Parkinson's disease (PD) is a neurodegenerative disease characterized by traditional motor features. Non-motor symptoms (NMS) are also seen in PD, which inevitably emerge through the disease progression and are often under-recognized and untargeted. Aims: We studied the prevalence of NMS in PD and their impact on health-related quality of life (HRQoL). Materials and Methods: A cross-sectional observational study from January 2017 to July 2017 of PD patients (n = 100) was done. NMS and HRQoL are measured using NMS scoring scale; PD questionnaire-39 and Hoehn and Yahr scale, respectively. Motor symptoms were assessed using scales for outcome in Parkinson's disease (SCoPA) - motor scoring scale. Statistical Analysis: Descriptive statistics calculated for NMS' prevalence. Continuous variables were assessed by two-tailed t-test and discrete and categorical variables by chi-square test. Multiple linear regression analysis was done among scoring scales to identify the influence on 39-item Parkinson's disease questionnaire (PDQ-39) scoring scale. All statistical data collected are analyzed with SSPS software version- 20 for windows. Results: In 100 study population, 66 were males and 34 females. The mean age was 68.35 years and median onset of duration of PD was 3.49 with 64.6% on treatment. Fatigue, pain, and lightheadedness were more prevalent NMS with 78%, 75%, and 69%, respectively. With regression analysis, strongest predictor was NMSS score (P = 0.000), with each unit increase, it is associated with nearly 0.65 increase in PDQ-39 score. Conclusion: Though motor symptoms define the disease, NMS have a larger impact on HRQoL in PD and on caregiver's life. Understanding the pattern and effect of NMS is needed for targeted treatment strategies.


中文翻译：

---

印度三级护理中心帕金森病非运动症状的患病率及其对生活质量的影响。


背景：帕金森病 (PD) 是一种以传统运动特征为特征的神经退行性疾病。非运动症状 (NMS) 也见于 PD，其不可避免地随着疾病进展而出现，并且通常未被充分认识和没有针对性。目的：我们研究了 NMS 在 PD 中的患病率及其对健康相关生活质量 (HRQoL) 的影响。材料与方法：对 2017 年 1 月至 2017 年 7 月的 PD 患者（ n = 100）进行横断面观察研究。NMS 和 HRQoL 使用 NMS 评分量表测量；PD 问卷 39 和 Hoehn 和 Yahr 量表分别。运动症状评估使用帕金森病 (SCoPA) 结果量表 - 运动评分量表。统计分析：为 NMS 的患病率计算的描述性统计。连续变量通过双尾 t 检验评估，离散变量和分类变量通过卡方检验评估。对评分量表进行多元线性回归分析，以确定对 39 项帕金森病问卷 (PDQ-39) 评分量表的影响。收集的所有统计数据均使用 SSPS 软件版本 20 for windows 进行分析。结果： 100名研究人群中，男性66人，女性34人。平均年龄为 68.35 岁，中位 PD 持续时间为 3.49，治疗率为 64.6%。疲劳、疼痛和头晕在 NMS 中更为普遍，分别为 78%、75% 和 69%。通过回归分析，最强的预测因子是 NMSS 评分（P= 0.000），每增加一个单位，PDQ-39 分数就会增加近 0.65。结论：虽然运动症状定义了疾病，但 NMS 对 PD 患者的 HRQoL 和护理人员的生活有更大的影响。有针对性的治疗策略需要了解 NMS 的模式和效果。