In this study, we investigated the utility of pentraxin 3 (PTX-3) in bronchoalveolar lavage fluid (BALF) as lung cancer (LCa) diagnostic. A total of 89 LCa patients and 84 non-LCa patients who received bronchoscopy in the First Affiliated Hospital of Xi’an Jiaotong University from December 2014 to February 2015 were enrolled. LCa was subdivided according to pathological type (scale, gland, and small cell lung cancer). BALF samples were obtained during bronchoscopy and PTX-3 levels assayed by ELISA. -tests, Mann-Whitney, and Kruskal-Wallis tests were performed for the comparison of PTX-3 levels between the different groups. Correlation analysis and receiver operating characteristic (ROC) analysis were used to analyze clinical data. The levels of PTX-3 increased in the LCa groups. PTX-3 levels were higher in the small cell lung cancer (SCLC) compared to non-small-cell lung cancer (NSCLC) groups. In LCa patients, obstructive pneumonia could upregulate the expression of PTX-3 in BALF. The area under the ROC curve of PTX-3 in BALF during LCa diagnosis, SCLC, and LCa with obstructive pneumonia was 0.949 (), 0.672 (), and 0.838 (), respectively. In conclusion, PTX-3 in BALF has a potential value as an LCa biomarker, particularly in cases of SCLC and LCa with obstructive pneumonia.

中文翻译：

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支气管肺泡灌洗液中的Pentraxin 3（PTX-3）水平作为肺癌的生物标志物。

在这项研究中，我们调查了五联蛋白3（PTX-3）在支气管肺泡灌洗液（BALF）中作为肺癌（LCa）诊断的实用性。纳入2014年12月至2015年2月在西安交通大学第一附属医院接受支气管镜检查的89位LCa患者和84位非LCa患者。LCa根据病理类型（规模，腺癌和小细胞肺癌）细分。在支气管镜检查期间获得BALF样品，并通过ELISA测定PTX-3水平。--进行了Mann-Whitney测试和Kruskal-Wallis测试，以比较不同组之间的PTX-3水平。相关分析和接收器工作特性（ROC）分析用于分析临床数据。LCa组中PTX-3的水平升高。与非小细胞肺癌（NSCLC）组相比，小细胞肺癌（SCLC）中的PTX-3水平更高。在LCa患者中，阻塞性肺炎可能会上调BALF中PTX-3的表达。LCa诊断，SCLC和LCa合并阻塞性肺炎期间，BALF中PTX-3的ROC曲线下面积为0.949（）， 0.672（）和0.838（）。总之，BALF中的PTX-3具有作为LCa生物标志物的潜在价值，特别是在SCLC和LCa合并阻塞性肺炎的情况下。