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Trans-NanoSim characterizes and simulates nanopore RNA-sequencing data.
GigaScience ( IF 9.2 ) Pub Date : 2020-06-10 , DOI: 10.1093/gigascience/giaa061
Saber Hafezqorani 1, 2 , Chen Yang 1, 2 , Theodora Lo 1 , Ka Ming Nip 1, 2 , René L Warren 1 , Inanc Birol 1, 3
Affiliation  

Compared with second-generation sequencing technologies, third-generation single-molecule RNA sequencing has unprecedented advantages; the long reads it generates facilitate isoform-level transcript characterization. In particular, the Oxford Nanopore Technology sequencing platforms have become more popular in recent years owing to their relatively high affordability and portability compared with other third-generation sequencing technologies. To aid the development of analytical tools that leverage the power of this technology, simulated data provide a cost-effective solution with ground truth. However, a nanopore sequence simulator targeting transcriptomic data is not available yet.

中文翻译:

Trans-NanoSim 表征和模拟纳米孔 RNA 测序数据。

与二代测序技术相比,三代单分子RNA测序具有前所未有的优势;它产生的长读长有助于同种型水平的转录本表征。尤其是牛津纳米孔技术测序平台与其他第三代测序技术相比,由于其相对较高的可负担性和便携性,近年来变得越来越流行。为了帮助开发利用这项技术的强大功能的分析工具,模拟数据提供了具有基本事实的经济高效的解决方案。然而,针对转录组数据的纳米孔序列模拟器尚不可用。
更新日期:2020-06-10
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