We report on the antibacterial activity of five phenolic lipids derived from anacardic acid characterized by increasing alkyl chain lengths with 6, 8, 10, 12, or 14 carbon atoms. The compounds were profiled for their physicochemical properties, transport across epithelial monolayers, cytotoxicity, and antibacterial activity as compared to common antibiotics. No cytotoxicity was reported in cell lines of fibroblast, hepatic, colorectal, or renal origin. C₁₀ and C₁₂ significantly increased the survival in a Galleria mellonella model infected with multi-drug-resistant Staphylococcus aureus (MRSA) or vancomycin-resistant Enterococci (VRE) as compared to the untreated control group. Future studies are required to corroborate these findings in relevant animal model systems of infection.

中文翻译：

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抗菌Anacardic酸衍生物。

我们报告了五种衍生自唐卡酸的酚类脂类的抗菌活性，其特征是增加了6、8、10、12或14个碳原子的烷基链长度。与常规抗生素相比，针对这些化合物的理化特性，跨上皮单层转运，细胞毒性和抗菌活性进行了分析。在成纤维细胞，肝，结肠直肠或肾脏来源的细胞系中没有细胞毒性的报道。C ₁₀和C ₁₂显着提高了被多重耐药金黄色葡萄球菌（MRSA）或耐万古霉素肠球菌感染的梅隆回廊模型的存活率（VRE）与未治疗的对照组相比。需要进一步的研究来证实相关感染动物模型系统中的这些发现。