In this study, a micropatterned scaffold with surface-loaded spherical bioactive glasses was successfully fabricated by the electrospinning technique and polydopamine (PDA) coating method for diabetic wound healing. The micro- to nanoscaled hierarchical structure and PDA coating could mimic the structure and function of the native extracellular matrix (ECM), and the scaffold could sustainably release the Si and Ca ions. The in vitro study revealed that the adhesion, proliferation, migration, and angiogenic differentiation of human umbilical vein endothelial cells could be significantly promoted by the scaffold. The in vivo experiment further revealed that the PDA-coated patterned scaffolds showed a high efficiency in diabetic wound healing and a significant improvement in re-epithelialization and collagen deposition in diabetic wounds. More importantly, the controllably released Si ions from the scaffold could further promote angiogenesis and inhibit inflammation in the wound site, thereby improving the healing quality of the diabetic wound. Our results suggest that this kind of scaffold with the ECM-mimicking structure and function as well as the released Si ions could be a promising treatment for diabetic wound.

中文翻译：

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一种受贻贝启发的细胞外基质模拟复合支架用于糖尿病伤口愈合

在这项研究中，采用静电纺丝技术和聚多巴胺 (PDA) 涂层方法成功地制造了具有表面负载球形生物活性玻璃的微图案支架，用于糖尿病伤口愈合。微米到纳米级的分层结构和 PDA 涂层可以模拟天然细胞外基质 (ECM) 的结构和功能，并且支架可以持续释放 Si 和 Ca 离子。体外研究表明，支架可显着促进人脐静脉内皮细胞的粘附、增殖、迁移和血管生成分化。体内_实验进一步表明，涂有 PDA 的图案化支架在糖尿病伤口愈合方面表现出高效率，并且在糖尿病伤口中的再上皮化和胶原蛋白沉积方面有显着改善。更重要的是，支架中可控释放的Si离子可以进一步促进血管生成，抑制创面炎症，从而提高糖尿病创面的愈合质量。我们的研究结果表明，这种具有 ECM 模拟结构和功能以及释放的 Si 离子的支架可能是治疗糖尿病伤口的有希望的方法。