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Poly(dl‐Lactic Acid)‐Based Linear Polyurethanes Capable of Forming Physical Crosslinking via UPy Quadruple Hydrogen Bonding Assembly
Macromolecular Materials and Engineering ( IF 3.9 ) Pub Date : 2020-06-09 , DOI: 10.1002/mame.202000042 Yimei Chen 1, 2 , Yanli Meng 1, 2 , Yanfeng Luo 1, 2 , Yuanliang Wang 1, 2
Macromolecular Materials and Engineering ( IF 3.9 ) Pub Date : 2020-06-09 , DOI: 10.1002/mame.202000042 Yimei Chen 1, 2 , Yanli Meng 1, 2 , Yanfeng Luo 1, 2 , Yuanliang Wang 1, 2
Affiliation
Linear shape memory polyurethanes based on poly(dl ‐lactic acid) (PDLLA) macrodiol (PDLLA‐SMPUs) have various advantages such as good processability, biodegradability, shape memory effect, and biocompatibility, yet the insufficient mechanical properties prevent their effective applications in bone repair. 2‐Ureido‐4[1H ]‐pyrimidone (UPy) can form strong quadruple hydrogen bonding. Here, a new linear PDLLA‐SMPU containing pendant UPy units (UPy‐p‐PDLLA‐SMPU) is designed and synthesized. The pendant UPy units may dimerize to form physical crosslinking among UPy‐p‐PDLLA‐SMPU chains. As a result, UPy‐p‐PDLLA‐SMPU demonstrates both good processability and significantly higher mechanical properties than the corresponding linear PDLLA‐SMPU without pendant UPys. In addition, UPy‐p‐PDLLA‐SMPU shows excellent shape memory effect near body temperature, with a shape fixity ratio of up to 98.6% and a recovery ratio of up to 92.9%. This work provides a new strategy to design SMPUs integrating the merits of linear and crosslinked polyurethanes, and the obtained UPy‐p‐PDLLA‐SMPU is a promising material for bone tissue repair in view of the mechanical, thermal, and shape memory properties.
中文翻译:
能够通过UPy四氢键结合组件形成物理交联的基于聚(dl-乳酸)的线性聚氨酯
基于聚(dl乳酸)(PDLLA)大二醇(PDLLA-SMPUs)的线性形状记忆聚氨酯具有各种优点,例如良好的可加工性,生物降解性,形状记忆效应和生物相容性,但是机械性能不足会阻止它们在骨骼中的有效应用修理。2‐Ureido‐4 [1 H ] ‐嘧啶酮(UPy)可以形成牢固的四氢键。在这里,设计并合成了一个新的线性PDLLA-SMPU,其中包含侧基UPy单元(UPy- p - PDLLA- SMPU)。挂件UPy单元可二聚化形成UPy-之间的物理交联p -PDLLA-SMPU链。其结果是,UPy- p‐PDLLA-SMPU与没有悬垂UPy的相应线性PDLLA-SMPU相比,具有很好的加工性能和显着更高的机械性能。此外,UPy- p -PDLLA-SMPU节目接近体温优异的形状记忆效应,与最多至98.6%的形状固定率和至多到92.9%的恢复率比。这项工作提供了设计SMPUs整合线性和交联的聚氨酯的优点的新策略,并将获得的UPy- p -PDLLA-SMPU为骨组织修复鉴于机械,热,和形状记忆特性的有前途的材料。
更新日期:2020-07-16
中文翻译:
能够通过UPy四氢键结合组件形成物理交联的基于聚(dl-乳酸)的线性聚氨酯
基于聚(dl乳酸)(PDLLA)大二醇(PDLLA-SMPUs)的线性形状记忆聚氨酯具有各种优点,例如良好的可加工性,生物降解性,形状记忆效应和生物相容性,但是机械性能不足会阻止它们在骨骼中的有效应用修理。2‐Ureido‐4 [1 H ] ‐嘧啶酮(UPy)可以形成牢固的四氢键。在这里,设计并合成了一个新的线性PDLLA-SMPU,其中包含侧基UPy单元(UPy- p - PDLLA- SMPU)。挂件UPy单元可二聚化形成UPy-之间的物理交联p -PDLLA-SMPU链。其结果是,UPy- p‐PDLLA-SMPU与没有悬垂UPy的相应线性PDLLA-SMPU相比,具有很好的加工性能和显着更高的机械性能。此外,UPy- p -PDLLA-SMPU节目接近体温优异的形状记忆效应,与最多至98.6%的形状固定率和至多到92.9%的恢复率比。这项工作提供了设计SMPUs整合线性和交联的聚氨酯的优点的新策略,并将获得的UPy- p -PDLLA-SMPU为骨组织修复鉴于机械,热,和形状记忆特性的有前途的材料。