The self‐assembly of polymers is a major topic in current polymer chemistry. In here, the self‐assembly of a pullulan based double hydrophilic block copolymer, namely pullulan‐b‐poly(N,N‐dimethylacrylamide)‐co‐poly(diacetone acrylamide) (Pull‐b‐(PDMA‐co‐PDAAM)) is described. The hydrophilic block copolymer induces phase separation at high concentration in aqueous solution. Additionally, the block copolymer displays aggregates at lower concentration, which show a size dependence on concentration. In order to stabilize the aggregates, crosslinking via oxime formation is described, which enables preservation of aggregates at high dilution, in dialysis and in organic solvents. With adequate stability by crosslinking, double hydrophilic block copolymer (DHBC) aggregates open pathways for potential biomedical applications in the future.

中文翻译：

---

聚（N，N-二甲基丙烯酰胺）-b-支链淀粉双亲水嵌段共聚物的聚集和交联

聚合物的自组装是当前聚合物化学中的一个主要主题。在这里，自组装一个支链淀粉的基于双亲水性嵌段共聚物，即pullulan- b -聚（N，N-二甲基丙烯酰胺） -共-聚（二丙酮丙烯酰胺）（上拉b - （PDMA-共-PDAAM））。亲水性嵌段共聚物在水溶液中以高浓度引起相分离。另外，嵌段共聚物在较低浓度下显示聚集体，其显示出对浓度的尺寸依赖性。为了稳定聚集体，描述了通过肟形成的交联，其能够以高稀释度在透析和有机溶剂中保存聚集体。通过交联具有足够的稳定性，双亲水嵌段共聚物（DHBC）聚集了未来潜在生物医学应用的开放途径。