Abstract In the present research, seven Mannich bases, bioactive compounds, as anticancer drug proposed which have different chemical composition has been studied comprehensively in terms of photons and charged particles protecting features. Aryl part of the compounds was changed as phenyl, 4-methylphenyl, 4-fluorophenyl, 4-bromophenyl, 4-methoxyphenyl, 4-nitrophenyl and 4-chlorophenyl. The experimental values of mass attenuation coefficients (μm) were obtained by the help of HPGe detector for 8.04–59.54 keV photon energies. Experimental results of μm were matched by the theoretical results which were found by using WinXCOM program. It has been obtained that the μm values of the samples, arly part is varied with 4-bromophenyl (S4) and 4-chlorophenyl (S7), are largest than that of other samples. In addition, other basic photon attenuation parameters, equivalent and effective atomic numbers (Zeq and Zeff) and energy absorption buildup factor (EABF) values for the proposed compounds have been achieved in the range of 0.015–15 MeV. While the highest Zeff and Zeq values belong to the S4 sample, the EABFs were obtained to be the smallest for the S4 sample according to the other sample. Lastly, the attenuating capacity of the compounds against charged particles such as alphas and protons was estimated by calculating the mass stopping power (MSP) and the range of the particles. The S4 sample with 4-bromophenyl aryl part was found to be outstanding in stopping alpha and proton particles. It was deduced that the S4 sample is a better drug candidate for photon and particle radiations protection applications among the other compounds. The present data will be useful to determine the radiation parameters of further drug candidates in medical oncology and nuclear medicine.

中文翻译：

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部分曼尼希碱生物活性化合物辐射防护特性的实验研究

摘要 在目前的研究中，从光子和带电粒子保护特性的角度，综合研究了七种曼尼希碱、生物活性化合物，作为具有不同化学成分的抗癌药物。化合物的芳基部分变为苯基、4-甲基苯基、4-氟苯基、4-溴苯基、4-甲氧基苯基、4-硝基苯基和4-氯苯基。质量衰减系数 (μm) 的实验值是在 HPGe 探测器的帮助下获得的，用于 8.04-59.54 keV 光子能量。μm 的实验结果与使用 WinXCOM 程序发现的理论结果相匹配。已经得到，样品的μm值，其中部分随4-溴苯基(S4)和4-氯苯基(S7)变化，比其他样品最大。此外，所提出化合物的其他基本光子衰减参数、等效和有效原子序数（Zeq 和 Zeff）以及能量吸收累积因子（EABF）值已在 0.015-15 MeV 范围内实现。虽然最高的 Zeff 和 Zeq 值属于 S4 样品，但根据其他样品，S4 样品的 EABF 最小。最后，通过计算质量停止能力 (MSP) 和粒子范围来估计化合物对带电粒子（如 α 和质子）的衰减能力。发现具有 4-溴苯基芳基部分的 S4 样品在阻止 α 和质子粒子方面表现出色。据推断，在其他化合物中，S4 样品是光子和粒子辐射防护应用的更好候选药物。