Two undescribed triterpenes, tricholimbrins A and B, three undescribed steroids, tricholimbrins C‒E, one undescribed 4-chromanone derivative, along with 27 known compounds were isolated from fruiting bodies of the mushroom Tricholoma imbricatum. Tricholimbrins A and B are two polycyclic triterpenoids with a carbon degradation, while tricholimbrin C is a ring-rearranged steroid containing an aromatic moiety that might be derived from an ergosterol. Isocyathisterol, 3β,15α-dihydroxyl-(22E,24R)-ergosta-5,8(14),22-trien-7-one, demethylincisterol A3, and volemolide showed cytotoxicities to six human cancer cell lines. 3β-Hydroxyl-(22E,24R)-ergosta-5,8,22-trien-7,15-dione and 3β-hydroxyl-(22E,24R)-ergosta-5,8,22-trien-7-one showed preferable cytotoxicities against HL-60 while chaxine C and volemolide showed preferable cytotoxicities against A-549, with IC50 values less than 10 μM.

中文翻译：

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蘑菇毛口蘑的化学成分及其细胞毒性

从蘑菇 Tricholoma imbricatum 的子实体中分离出两种未描述的三萜类 Tricholimbrins A 和 B、三种未描述的类固醇 Tricholimbrins C-E、一种未描述的 4-色满酮衍生物以及 27 种已知化合物。Tricholimbrins A 和 B 是两种碳降解的多环三萜类化合物，而 Tricholimbrin C 是一种环重排的类固醇，含有可能来自麦角甾醇的芳香部分。Isocyathisterol、3β,15α-dihydroxyl-(22E,24R)-ergosta-5,8(14),22-trien-7-one、demethylincisterol A3 和 volemolide 对六种人类癌细胞系显示出细胞毒性。3β-Hydroxyl-(22E,24R)-ergosta-5,8,22-trien-7,15-dione 和 3β-hydroxyl-(22E,24R)-ergosta-5,8,22-trien-7-one对 HL-60 有较好的细胞毒性，而 chaxine C 和伏尔莫利特对 A-549 有较好的细胞毒性，