Background: Oleamide is an essential substance for human health. So, the plants with high oleamide content are great sources for health care products.

Objective: This study is conducted to investigate the quality of oleamide in plants and test the bioactivity in the selected two studied species.

Methods: The three Ipomoea and five Dillenia species including Ipomoea alba, Ipomoea aquatica and Ipomoea pes-caprae, and Dillenia indica, Dillenia obovata, Dillenia ovata, Dillenia parviflora and Dillenia pentagyna were investigated for the quantity of oleamide by high-performance liquid chromatography. The biological activity test was conducted on the powder formulation of the chosen plants, Dillenia ovata and Dillenia parviflora at a ratio of 30:70, for anti-inflammatory activity ex vivo on a panel of molecular targets through ion channel inhibition including voltage-gated sodium channel, voltage-gated potassium channel, and the cardiac ion as human ether-a-go-go related gene.

Results: The results showed that the leaf extracts of I. aquatica and D. ovata gave the highest and subsequent oleamide quantity i.e. 7.52 and 5.17 mg/g, respectively. Out of the Dillenia formulation which contained various compounds, oleamide showed the highest percentages of inhibition at 8.0-20.0%, and 6.2-14.2% in voltage-gated sodium channel, and voltage-gated potassium channel which had slightly lower values than the oleamide standard, and no effect as 0.0% value inhibition in the cardiac ion channel.

Conclusion: The Dillenia formulation exhibits anti-inflammatory activity without affecting the heart. Accordingly, the three studied Ipomoea and three studied Dillenia species may be used for the same activity as a single component or formulation with effective solvent for disease treatments.

背景：油酰胺是人类健康必不可少的物质。因此，具有高油酰胺含量的植物是保健产品的重要来源。

目的：本研究旨在调查植物中油酰胺的质量，并测试所选的两个研究物种的生物活性。

方法：通过高效液相色谱法对3种番薯属和5种Dillenia物种（包括白斑番薯，水生番薯和大叶番薯）以及Dillenia indica，Dillenia obovata，Dillenia ovata，Dillenia parviflora和Dillenia pentagyna进行了高效液相色谱分析。生物学活性测试是针对所选植物的卵形Dillenia ovata和Dillenia parviflora的粉末制剂，以30:70的比例进行的，以通过离子通道抑制（包括电压门控钠盐）对一系列分子靶标进行离体抗炎活性通道，电压门控钾通道和心脏离子作为人类以太相关基因。

结果：结果表明，水生伊豆和卵形杜鹃的叶提取物提供最高和随后的油酰胺量，分别为7.52和5.17 mg / g。在含有各种化合物的Dillenia制剂中，油酰胺在电压门控钠通道和电压门控钾通道中的抑制率最高，分别为8.0-20.0％和6.2-14.2％，其值略低于油酰胺标准品。 ，并且对心脏离子通道的0.0％值抑制没有影响。

结论：Dillenia制剂具有抗炎活性，且不影响心脏。因此，可以将三种研究的番薯属和三种研究的丁香属植物用作具有有效溶剂的单一组分或制剂的相同活性，以用于疾病治疗。