The capacities for neural stem cells (NSCs) self-renewal with differentiation are need to be precisely regulated for ensuring brain development and homeostasis. Recently, increasing number of studies have highlighted that long non-coding RNAs (lncRNAs) are associated with NSC fate determination during brain development stages. LncRNAs are a class of non-coding RNAs more than 200 nucleotides without protein-coding potential and function as novel critical regulators in multiple biological processes. However, the correlation between lncRNAs and NSC fate decision still need to be explored in-depth. In this review, we will summarize the roles and molecular mechanisms of lncRNAs focusing on NSCs self-renewal, neurogenesis and gliogenesis over the course of neural development, still more, dysregulation of lncRNAs in all stage of neural development have closely relationship with development disorders or glioma. In brief, lncRNAs may be explored as effective modulators in NSCs related neural development and novel biomarkers for diagnosis and prognosis of neurological disorders in the future.

中文翻译：

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长非编码RNA在神经干细胞增殖和分化中的功能。

需要精确调节神经干细胞（NSC）自我更新的能力，以确保大脑发育和体内平衡。最近，越来越多的研究强调，长非编码RNA（lncRNA）与大脑发育阶段的NSC命运决定有关。LncRNA是一类超过200个核苷酸的非编码RNA，没有蛋白质编码的潜能，在多种生物过程中起着新的关键调节剂的作用。然而，lncRNA与NSC命运决定之间的相关性仍需深入探讨。在这篇综述中，我们将总结在神经发育过程中着眼于NSC自我更新，神经发生和神经胶质发生的lncRNA的作用和分子机制，此外，在神经发育的所有阶段中，lncRNA的失调与发育障碍或神经胶质瘤密切相关。简而言之，lncRNAs可能在NSCs相关的神经发育中被探索为有效的调节剂，并在未来用于诊断和预测神经系统疾病的新型生物标志物。