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Hyperpolarization-Enhanced NMR Spectroscopy with Femtomole Sensitivity Using Quantum Defects in Diamond
Physical Review X ( IF 12.5 ) Pub Date : 2020-06-09 , DOI: 10.1103/physrevx.10.021053
Dominik B. Bucher , David R. Glenn , Hongkun Park , Mikhail D. Lukin , Ronald L. Walsworth

Nuclear magnetic resonance (NMR) spectroscopy is a widely used tool for chemical analysis and molecular structure identification. Because it typically relies on the weak magnetic fields produced by a small thermal nuclear spin polarization, NMR suffers from poor molecule-number sensitivity compared to other analytical techniques. Recently, a new class of NMR sensors based on optically probed nitrogen-vacancy (NV) quantum defects in diamond have allowed molecular spectroscopy from sample volumes several orders of magnitude smaller than the most sensitive inductive detectors. To date, however, NV NMR spectrometers have only been able to observe signals from pure, highly concentrated samples. To overcome this limitation, we introduce a technique that combines picoliter-scale NV NMR with fully integrated Overhauser dynamic nuclear polarization to perform high-resolution spectroscopy on a variety of small molecules in dilute solution, with femtomole sensitivity. Our technique advances the state of the art of mass-limited NMR spectroscopy, opening the door to new applications at the picoliter scale in drug and natural-product discovery, catalysis research, and single-cell studies.

中文翻译:

利用金刚石中的量子缺陷实现具有飞摩尔分子敏感性的超极化增强NMR光谱

核磁共振(NMR)光谱是化学分析和分子结构鉴定中广泛使用的工具。由于NMR通常依赖于小的热核自旋极化产生的弱磁场,因此与其他分析技术相比,NMR具有较差的分子数灵敏度。最近,基于钻石中光学探测的氮空位(NV)量子缺陷的新型NMR传感器已使来自样品体积的分子光谱能够比最灵敏的感应探测器小几个数量级。但是,迄今为止,NV NMR光谱仪只能观察到来自纯净,高度浓缩样品的信号。为了克服此限制,我们介绍了一种将皮升级NV NMR与完全集成的Overhauser动态核极化相结合的技术,可对具有飞摩尔灵敏度的稀溶液中的各种小分子进行高分辨率光谱分析。我们的技术推动了质量限制NMR光谱技术的发展,在药物和天然产物发现,催化研究和单细胞研究中以微微升规模打开了新的应用之门。
更新日期:2020-06-09
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