Introduction

Diabetes mellitus (DM) is a highly prevalent, chronic condition in adults worldwide. Little is known about the potential role of diabetes as an effect modifier of vaccine protective responses.

Areas covered

We conducted a literature review of the immunogenicity, efficacy and effectiveness of immunization in individuals, in studies that compared subjects with DM (DM+) and without DM (DM-). We found few published studies, which were only for vaccines against hepatitis B, influenza, pneumococcal disease, or varicela zoster. Except for a consistent attenuation of the immune response to hepatitis B vaccine among DM+ individuals, we found little other consistent evidence for DM as an effect modifier of vaccine responses.

Expert opinion

There are substantial gaps in our knowledge of the impact of DM on the immune response to immunization or effect of vaccination.

中文翻译：

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糖尿病作为疫苗效果改良剂的评论

介绍

糖尿病（DM）是全世界成年人中高度流行的慢性疾病。关于糖尿病作为疫苗保护反应的效应调节剂的潜在作用知之甚少。

覆盖区域

在比较患有DM（DM +）和不患有DM（DM-）的受试者的研究中，我们对个体的免疫原性，免疫效力和有效性进行了文献综述。我们发现很少有已发表的研究，这些研究仅针对抗乙型肝炎，流感，肺炎球菌疾病或带状疱疹的疫苗。除了在DM +个体中对乙型肝炎疫苗的免疫应答持续减弱外，我们几乎没有其他一致的证据证明DM作为疫苗应答的作用调节剂。

专家意见

在我们对DM对免疫的免疫反应或接种效果的影响的认识方面，存在很大的差距。