当前位置: X-MOL 学术J. Immunol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
FCRL4 Is an Fc Receptor for Systemic IgA, but Not Mucosal Secretory IgA
The Journal of Immunology ( IF 4.4 ) Pub Date : 2020-06-08 , DOI: 10.4049/jimmunol.2000293
Yanling Liu 1 , Sofiya Goroshko 1 , Leslie Y T Leung 1 , Shilan Dong 1 , Srijit Khan 1 , Paolo Campisi 2 , Evan J Propst 2 , Nikolaus E Wolter 2 , Eyal Grunebaum 3 , Götz R A Ehrhardt 4
Affiliation  

Key Points FCRL4 recognizes systemic J chain–linked IgA. FCRL4 recognition of J chain–linked IgA can be inhibited by secretory component. Primary FCRL4+ memory B cells are decorated with systemic J chain–linked IgA. Fc receptor–like (FCRL) 4 is an immunoregulatory receptor expressed on a subpopulation of human memory B cells of mucosa-associated lymphoid tissue. Fc receptor function of FCRL4 was demonstrated by binding of IgA to FCRL4 following heat aggregation of the Ig. In this study, we demonstrate that FCRL4 recognizes J chain–linked systemic IgA in the absence of heat aggregation. We further demonstrate that mucosal secretory IgA is not recognized by FCRL4 and that systemic IgA binding can be competitively inhibited by recombinant secretory component protein. Finally, we provide evidence that primary FCRL4-bearing human memory B cells are constitutively bound to IgA. Our study provides a mechanism for the negative regulatory activity of FCRL4 on AgR-mediated B cell activation.

中文翻译:

FCRL4 是全身性 IgA 的 Fc 受体,但不是粘膜分泌性 IgA

关键点 FCRL4 识别系统性 J 链连接的 IgA。FCRL4 识别 J 链连接的 IgA 可以被分泌成分抑制。初级 FCRL4+ 记忆 B 细胞被系统性 J 链连接的 IgA 修饰。Fc 受体样 (FCRL) 4 是一种免疫调节受体,在粘膜相关淋巴组织的人类记忆 B 细胞亚群上表达。FCRL4 的 Fc 受体功能通过 IgA 在 Ig 热聚集后与 FCRL4 的结合来证明。在这项研究中,我们证明 FCRL4 在没有热聚集的情况下识别 J 链连接的全身性 IgA。我们进一步证明,FCRL4 不识别粘膜分泌型 IgA,并且重组分泌成分蛋白可以竞争性抑制全身性 IgA 结合。最后,我们提供的证据表明,携带初级 FCRL4 的人类记忆 B 细胞与 IgA 组成型结合。我们的研究为 FCRL4 对 AgR 介导的 B 细胞活化的负调节活性提供了一种机制。
更新日期:2020-06-08
down
wechat
bug