Gastrointestinal (GI) dysfunction, including constipation, is a common non‐motor symptom of Parkinson's disease (PD). The toxin 6‐hydroxydopamine (6OHDA) produces the symptoms of PD, surprisingly including constipation, after it is injected into the medial forebrain bundle (MFB). However, the mechanisms involved in PD‐associated constipation caused by central application of 6OHDA remain unknown. We investigated effects of 6OHDA lesioning of the MFB on motor performance and GI function.

中文翻译：

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对黑质纹状体多巴胺能神经元病变产生的帕金森病模型中介导结直肠功能障碍的神经通路的研究。

胃肠道功能障碍（包括便秘）是帕金森氏病（PD）的常见非运动症状。将毒素6-羟基多巴胺（6OHDA）注射入前脑内侧束（MFB）后，会产生PD的症状，令人惊讶地包括便秘。然而，由6OHDA的集中应用引起的PD相关性便秘的机制仍不清楚。我们调查了MFB的6OHDA损伤对运动性能和胃肠道功能的影响。