With the rapid increase of aquaculture contributing to sustainable food security, comes the need to better understand seafood associated diseases. One of the major aquatic bacterial genera responsible for human infections from seafood is Vibrio, especially from oysters. Currently, in vivo study of bacterial interactions within oysters is limited by the inability to promote high‐level uptake of bacteria by oysters. This study has therefore evolved current natural marine snow protocols to generate ‘artificial’ marine snow, into which bacteria can be incorporated to facilitate extensive uptake by oysters. This presents an adaptable model for bacterial study within filter‐feeding shellfish. Using this model, we demonstrate for the first time the antibacterial activity of Vibrio vulnificus Type 6 secretion systems in vivo, revealing an important role for the T6SS in V. vulnificus ecology.

中文翻译：

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普遍的牡蛎感染模型表明，创伤弧菌6型分泌系统在体内具有抗菌活性。

随着水产养殖的迅速发展为可持续的粮食安全做出贡献，需要更好地了解与海鲜有关的疾病。引起人类从海鲜中感染的主要水生细菌属之一是弧菌，尤其是牡蛎。目前，由于无法促进牡蛎对细菌的高水平吸收，因此对牡蛎内细菌相互作用的体内研究受到了限制。因此，这项研究已经发展了当前的天然海洋降雪方案，以产生“人​​造”海洋降雪，可以将细菌掺入其中以促进牡蛎的大量吸收。这为滤食性贝类细菌的研究提供了一种适应性模型。使用该模型，我们首次证明了抗菌素的抗菌活性。体内的创伤弧菌6型分泌系统揭示了V6中T6SS的重要作用。创伤生态学。