Insect‐microbial symbioses have vast biochemical diversity, which is beneficial to produce bioactive secondary metabolites. In this study, chemical examination of a Streptomyces sp. associated with a mud dauber wasp led to the isolation of fourteen compounds. Their structures were determined by spectroscopic methods and comparison with literature data. Among the isolates, compounds 1,2,3‐benzotriazin‐4(1H)‐one and 4‐(2‐aminoethyl)phenyl acetate were first reported from this species. Bioactivities of the isolated compounds were assayed for the first time against hexokinase II. 4‐(2‐Aminoethyl)phenyl acetate, germicidin B, phenylacetic acid, isogermicidin A and germicidin C displayed significant inhibitory activity against hexokinase II, with the IC50 values of 5.11, 7.11, 7.15, 8.45 and 8.78 μM, respectively.

中文翻译：

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来自链霉菌属的次级代谢产物的己糖激酶 II 抑制作用。与 Mud Dauber 黄蜂有关

昆虫-微生物共生具有广泛的生化多样性，有利于产生具有生物活性的次级代谢产物。在这项研究中，链霉菌属的化学检查。与泥涂器黄蜂相关联导致了十四种化合物的分离。它们的结构是通过光谱方法确定的，并与文献数据进行比较。在这些分离物中，化合物 1,2,3-苯并三嗪-4(1H)-one 和 4-(2-氨基乙基) 苯乙酸酯是该物种中首次报道的。首次针对己糖激酶 II 测定了分离化合物的生物活性。4-（2-氨基乙基）苯乙酸酯、杀菌素 B、苯乙酸、异杀菌素 A 和杀菌素 C 对己糖激酶 II 显示出显着的抑制活性，IC50 值分别为 5.11、7.11、7.15、8.45 和 8.78 μM。