Emerging as a cost‐effective and robust enzyme mimic, nanozymes have drawn increasing attention with broad applications ranging from cancer therapy to biosensing. Developing nanozymes with both accelerated and inhibited biocatalytic properties in a biological context is intriguing to peruse more advanced functions of natural enzymes, but remains challenging, because most nanozymes are lack of enzyme‐like molecular structures. By re‐visiting and engineering the well‐known Fe‐N‐C electrocatalyst that has a heme‐like Fe‐N_x active sites, herein, it is reported that Fe‐N‐C could not only catalyze drug metabolization but also had inhibition behaviors similar to cytochrome P450 (CYP), endowing it a potential replacement of CYP for preliminary evaluation of massive potential chemicals, drug dosing guide, and outcome prediction. In addition, in contrast to electrocatalysts, the highly graphitic framework of Fe‐N‐C may not be obligatory for a competitive CYP‐like activity.

中文翻译：

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具有加速和抑制的生物催化活性的Fe-NC纳米酶能够访问药物-药物相互作用。

纳米酶已成为一种具有成本效益且功能强大的酶模拟物，在癌症治疗到生物传感等广泛应用中引起了越来越多的关注。在生物学环境中开发具有加速和抑制生物催化特性的纳米酶很有趣，可以研究天然酶的更高级功能，但仍然具有挑战性，因为大多数纳米酶缺乏酶样分子结构。通过重新访问和设计具有类似血红素Fe-N _x的著名Fe-N-C电催化剂活性位点，据报道，Fe-N-C不仅可以催化药物代谢，而且具有与细胞色素P450（CYP）相似的抑制行为，为潜在的大规模潜在化学物质的初步评估，药物剂量提供了可能替代CYP的潜力指南和结果预测。此外，与电催化剂相比，Fe-N-C的高度石墨框架可能不是竞争性CYP样活性的必需条件。