An amphiphilic metallo-supramolecular poly(propylene glycol)-block-poly(ethylene glycol) block copolymer containing a bis(2,2′:6′,2″-terpyridine) ruthenium (II) complex as a supramolecular connection between the two constituting blocks was used to prepare stable aqueous micelles which displayed a high intensity focused ultrasound (HIFU) triggered release behavior. By adjusting the HIFU time and intensity, the novel modality of HIFU triggered release allows for fine-tuning of the release kinetics of the encapsulants from the micelles in a remote and controlled way. Nuclear magnetic resonance spectroscopy, ultraviolet spectroscopy, and matrix-assisted laser desorption/ionization-time of flight mass spectrometry confirmed that the degradation of the micelles was due to the cleavage of the ether bond connected to the pyridine ring. This well controlled HIFU-copolymer micelle drug delivery system has considerable potential in targeted therapy.

包含双（2,2'：6'，2''-三吡啶）钌（II）配合物作为两分子之间的超分子连接的两亲性金属-超分子聚（丙二醇）-嵌段-聚（乙二醇）嵌段共聚物块用于制备稳定的水性胶束，其表现出高强度聚焦超声（HIFU）触发的释放行为。通过调节HIFU时间和强度，HIFU触发释放的新颖方式允许以远程和​​受控的方式微调封装剂从微团的释放动力学。核磁共振波谱，紫外线波谱和基质辅助激光解吸/电离飞行时间质谱法证实，胶束的降解是由于与吡啶环相连的醚键断裂所致。