Pharmacology Biochemistry and Behavior ( IF 3.6 ) Pub Date : 2020-06-09 , DOI: 10.1016/j.pbb.2020.172965 Hanna M Molla 1 , Kuei Y Tseng 2
As cannabinoid use among the adolescent population becomes widespread with recent legalizations, understanding more about its effects on the developing brain becomes increasingly important. Adolescent cannabinoid use has been shown to elicit both short and long lasting effects on cortical function, in part due to its impact on maturing brain regions including the prefrontal cortex and associated inputs. This paper provides an overview of current state of knowledge on the lasting impact of repeated cannabinoid exposure on behavior and associated neural circuits in adolescents compared to other age groups. Data obtained from human and rodent literature are integrated to discuss potential neural mechanisms underpinning the enduring negative impact of cannabinoid exposure during this sensitive period of brain development.
中文翻译:
青春期大麻素暴露负面影响的潜在神经底物。
随着大麻素在青少年人群中的使用随着最近的合法化变得越来越普遍,更多地了解其对发育中的大脑的影响变得越来越重要。已证明青少年大麻素的使用会对皮层功能产生短期和长期的影响,部分原因是它对成熟的大脑区域(包括前额叶皮层和相关输入)产生影响。本文概述了与其他年龄组相比,反复接触大麻素对青少年行为和相关神经回路的持久影响的当前知识状态。整合了从人类和啮齿动物文献中获得的数据,以讨论在大脑发育的这个敏感时期,大麻素暴露对持久负面影响的潜在神经机制。