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Three simple metrics to define in vitro fertilization success rates
Fertility and Sterility ( IF 6.7 ) Pub Date : 2020-07-01 , DOI: 10.1016/j.fertnstert.2020.04.056
Catha Fischer 1 , Richard T Scott 2
Affiliation  

Describing clinical outcomes from assisted reproduction technology (ART) treatment cycles has been an evolving challenge throughout the world. Three simple metrics provide a transparent and highly accurate summary of ART outcomes. The first metric is the probability of having no embryos available to transfer. This metric incorporates all causes of failure from initiation of the treatment cycle up to the point immediately before actual embryo transfer. Patients will know what the risk is of failing, whether it is due to poor follicular stimulation, failed fertilization, poor embryo development, or abnormal preimplantation genetic testing for aneuploidy (PGT-A) results. The second and most important metric is sustained implantation rate: the probability that any transferred embryo will implant and progress to delivery. In the event of a single-embryo transfer, the metric is identical to delivery rate per transfer. By calculating per embryo, it provides a summary of the quality of outcomes within the program without the obscuring effect of multiple-embryo transfer. The final metric is the number of supernumerary embryos cryopreserved during the cycle. This speaks to the efficiency of the process by providing an estimate of potential benefits which may come from an additional transfer should the first one be unsuccessful or even to allow the couple to pursue an additional child without another full ART cycle. These metrics are easy to calculate and provide a detailed picture of the outcomes attained by the program.

中文翻译:

定义体外受精成功率的三个简单指标

描述辅助生殖技术 (ART) 治疗周期的临床结果一直是世界范围内不断发展的挑战。三个简单的指标提供了对 ART 结果的透明且高度准确的总结。第一个指标是没有可供移植的胚胎的概率。该指标包含从治疗周期开始到实际胚胎移植之前的所有失败原因。患者将知道失败的风险是什么,无论是由于卵泡刺激不良、受精失败、胚胎发育不良还是非整倍体 (PGT-A) 结果的异常植入前基因检测。第二个也是最重要的指标是持续植入率:任何移植的胚胎将植入并进行交付的可能性。在单胚胎移植的情况下,指标与每次移植的交付率相同。通过计算每个胚胎,它提供了程序内结果质量的摘要,而不会掩盖多胚胎移植的影响。最后一个指标是周期中冷冻保存的多余胚胎的数量。如果第一个转移不成功,甚至允许这对夫妇在没有另一个完整的 ART 周期的情况下追求额外的孩子,这通过提供可能来自额外转移的潜在收益的估计来说明该过程的效率。这些指标易于计算,并提供了该计划所取得成果的详细图景。它提供了计划内结果质量的摘要,而不会掩盖多胚胎移植的影响。最后一个指标是周期中冷冻保存的多余胚胎的数量。如果第一个转移不成功,甚至允许这对夫妇在没有另一个完整的 ART 周期的情况下追求额外的孩子,这通过提供可能来自额外转移的潜在收益的估计来说明该过程的效率。这些指标易于计算,并提供了该计划所取得成果的详细图景。它提供了计划内结果质量的摘要,而不会掩盖多胚胎移植的影响。最后一个指标是周期中冷冻保存的多余胚胎的数量。如果第一个转移不成功,甚至允许这对夫妇在没有另一个完整的 ART 周期的情况下追求额外的孩子,这通过提供可能来自额外转移的潜在收益的估计来说明该过程的效率。这些指标易于计算,并提供了该计划所取得成果的详细图景。如果第一个转移不成功,甚至允许这对夫妇在没有另一个完整的 ART 周期的情况下追求额外的孩子,这通过提供可能来自额外转移的潜在收益的估计来说明该过程的效率。这些指标易于计算,并提供了该计划所取得成果的详细图景。如果第一个转移不成功,甚至允许这对夫妇在没有另一个完整的 ART 周期的情况下追求额外的孩子,这通过提供可能来自额外转移的潜在收益的估计来说明该过程的效率。这些指标易于计算,并提供了该计划所取得成果的详细图景。
更新日期:2020-07-01
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