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Efficiency comparison of experimental fosfatriclaben with three commercial fasciolicides in experimentally infected sheep.
Parasitology Research ( IF 2 ) Pub Date : 2020-06-09 , DOI: 10.1007/s00436-020-06705-4
Rosa Arias-García 1 , Yolanda Vera-Montenegro 1 , Miguel Flores-Ramos 1 , Rafael Castillo 2 , Alicia Hernández-Campos 2 , Froylán Ibarra-Velarde 1
Affiliation  

In this work, we compare and evaluate the efficiency of fosfatriclaben with three commercial fasciolicides in experimentally infected sheep. Fosfatriclaben is a novel prodrug derived from triclabendazole; it is highly water-soluble with excellent aqueous stability at pH 7, properties that make it ideal for developing intramuscular pharmaceutical compositions in the form of solutions. In order to compare, 30 mixed breed sheep, previously diagnosed negative to fluke eggs, were infected with 200 metacercariae of Fasciola hepatica, twice. Five groups of six animals/each were formed for treatments. Group 1 (G1) was treated with closantel 5% injectable at 5 mg/kg subcutaneously, G2 with clorsulon at 2 mg/kg subcutaneously, G3 with triclabendazole at 12 mg/kg per os, G4 with fosfatriclaben at 6 mg/kg intramuscularly (dose equivalent to triclabendazole content), and G5 remained as the non-treated control. On day 110, fecal samples were examined to determine the percentage of egg reduction after treatment, and sheep were humanely euthanized. The livers were collected, the flukes were extracted, measured, and counted. Efficiency in egg reduction was of 86.8, 90.5, 98.4, and 97.3% for closantel, clorsulon, triclabendazole, and fosfatriclaben, respectively, and efficiency against flukes was of 96.2, 91.9, 99.4, and 95.7%, respectively. No statistical differences were found between treatments. It is concluded that fosfatriclaben at 6 mg/kg intramuscularly presented a high fasciolicide efficiency, similar to the best commercial fasciolicides, having advantage over its predecessor since it uses half of the dose required by triclabendazole to remove flukes in sheep under study.



中文翻译:

实验性灭草灵与三种市售杀虫剂在实验性感染绵羊中的效率比较。

在这项工作中,我们比较和评估了福斯拉卡宾与三种市售的杀草剂在实验感染绵羊中的功效。Fosfatriclaben是一种源自三氯苯达唑的新型前药。它是高度水溶性的,在pH 7下具有出色的水稳定性,其特性使其成为开发溶液形式的肌内药物组合物的理想选择。为了进行比较,对30只先前被诊断对fl虫卵呈阴性的混合品种绵羊感染了200株Fasciola hepatica肝cer,两次。形成五组,每只动物六只,用于治疗。第1组(G1)分别经皮下注射5 mg / kg的5%氯沙泰尔,皮下注射2 mg / kg的克苏仑,G2口服三苯乙达唑的12 mg / kg os,G4联合草酸拉巴坦的6 mg / kg肌注(剂量相当于三氯苯达唑含量),G5仍作为未处理的对照。在第110天,检查粪便样品以确定处理后鸡蛋减少的百分比,并对绵羊进行人道安乐死。收集肝脏,提取,测量和计数吸虫。氯沙坦,克洛苏隆,三氯苯达唑和磷曲霉烯的减蛋效率分别为86.8、90.5、98.4和97.3%,而抗吸虫效果分别为96.2、91.9、99.4和95.7%。治疗之间未发现统计学差异。结论是,肌肉注射磷草胺6 mg / kg具有很高的杀稻草剂效率,类似于最佳的杀草剂,具有优于其前身的优势,因为它使用了三苯达唑所需剂量的一半来清除正在研究的绵羊体内的吸虫。

更新日期:2020-06-09
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