Background: Along with the developing technology in the modern age, physical activity had decreased considerably in children and adolescents alike with a concomittant and rapid increase in the prevalence of childhood obsesity. The purpose of the present study is to measure the levels of serum nesfatin-1 and irisin in obese children. Methods: The present study was carried out with a total of 62 children, including 32 obese children diagnosed between June 2017 and October 2017 and 30 healthy children. Serum nesfatin-1, irisin, SOD,MDA, fasting blood glucose, total cholesterol (TC), triglyceride (TG), HDL-C, LDL-C, aspartate amino transferase (AST), alanine amino transferase (ALT)), blood urea nitrogen (BUN), C-reactive protein (CRP), calcium (Ca), sodium (Na), potassium (P), chromium (Cr), ferritin, and vitamin B₁₂ data were collected for each patient. Results: In our study, mean nesfatin-1 and SOD values of the obesity group were lower than those of the control group (p <0.05, p <0.001), whereas irisin and MDA values were higher than those of the control group (p <0.001). Conclusion: Childhood obesity is still a significant global problem, despite increased social awareness and numerous preventive healthcare interventions. We believe that all the prospective studies to be carried out to evaluate the relationship between obesity-irisin-nesfatin-1 triad, will make positive contributions to treatment of obesity.

中文翻译：

---

肥胖儿童的血清nesfatin-1和鸢尾素水平。

背景：随着现代技术的发展，儿童和青少年的体育活动已大大减少，同时儿童肥胖症的患病率也随之迅速增加。本研究的目的是测量肥胖儿童的血清nesfatin-1和虹膜素的水平。方法：本研究共对62名儿童进行了研究，其中包括2017年6月至2017年10月期间诊断出的32名肥胖儿童和30名健康儿童。血清nesfatin-1，虹膜素，SOD，MDA，空腹血糖，总胆固醇（TC），甘油三酸酯（TG），HDL-C，LDL-C，天冬氨酸氨基转移酶（AST），丙氨酸氨基转移酶（ALT）），血液收集每位患者的尿素氮（BUN），C反应蛋白（CRP），钙（Ca），钠（Na），钾（P），铬（Cr），铁蛋白和维生素B ₁₂数据。结果：在我们的研究中，肥胖组的平均nesfatin-1和SOD值低于对照组（p <0.05，p <0.001），而虹膜素和MDA值高于对照组（p <0.001）。结论：尽管社会意识增强，并且采取了许多预防性保健措施，但儿童肥胖仍然是一个全球性的重大问题。我们相信，将进行的所有前瞻性研究以评估肥胖症-伊里森-nesfatin-1三联体之间的关系，将为肥胖症的治疗做出积极的贡献。