Human paraoxonase-1 (PON1) is a hydrolytic enzyme related in the onset, establishment, and progression of inflammatory illnesses, including cardiovascular diseases (CVD). Therefore, the primary goal of this investigation was to determinate the influence of the PON1 gene polymorphism (Q192R) on prognostic biomarkers of CVD in women (n = 350) from San Luis Potosi, Mexico. For everyone enrolled, anthropometric, clinical, and biochemical measurements were acquired. Q192R polymorphism of the PON1 gene was assessed by real-time PCR using TaqMan probes. Also, quantification and/or calculation of suggested predictive CVD biomarkers were completed. The association between PON1(Q192R) polymorphism with clinical predictive CVD biomarkers was assessed using univariate and multivariate logistic regression models. Genotype PON1 (Q192R) frequencies were: 18%, 47% and 35% for QQ, QR, and RR, respectively. Besides, the frequency of the variant R allele was 0.58. Furthermore, robust significant associations were found between PON1 (Q192R) polymorphism with serum ADMA [OR (95% CI); 3.50 (1.20–5.00), p < 0.01]; FABP4 [2.50 (2.15–3.95), p < 0.01]; and miR-126 [1.50 (1.15–2.00), p < 0.01] levels after adjusting for probable confounders. Data found in this research strongly support the notion that proposes a crucial role of PON1 enzyme (Q192R polymorphism) as a genetic determinant in the CVD risk in Mexican women.

人对氧磷酶-1（PON1）是一种水解酶，与包括心血管疾病（CVD）在内的炎性疾病的发作，建立和发展有关。因此，本研究的主要目的是确定PON1基因多态性（Q192R）对女性CVD预后生物标志物的影响（n = 350）来自墨西哥圣路易斯波托西。对于每个注册的人，都进行了人体测量，临床和生化测量。使用TaqMan探针通过实时PCR评估PON1基因的Q192R多态性。而且，完成了建议的预测性CVD生物标志物的定量和/或计算。PON1（Q192R）基因多态性与临床预测性CVD生物标志物之间的关联使用单变量和多变量logistic回归模型进行评估。基因型PON1（Q192R）频率分别为：QQ，QR和RR分别为18％，47％和35％。此外，变体R等位基因的频率为0.58。此外，发现PON1（Q192R）多态性与血清ADMA [OR（95％CI）；3.50（1.20–5.00），p  <0.01]；FABP4 [2.50（2.15-3.95），第 <0.01];  调整可能的混杂因素后，miR-126 [1.50（1.15–2.00），p <0.01]水平。这项研究中发现的数据强烈支持这一观点，该观点提出了PON1酶（Q192R多态性）作为墨西哥女性CVD风险的遗传决定因素的关键作用。