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Genome sequence analysis of a novel Enterobacter cloacae phage, Ec_L1, belonging to the genus Eclunavirus.
Archives of Virology ( IF 2.7 ) Pub Date : 2020-06-08 , DOI: 10.1007/s00705-020-04672-w
Hongyu Ren 1 , Zhen Li 2, 3 , Xiaoyu Li 1 , Lili Wang 1 , Yongping Xu 1, 2
Affiliation  

Phages, viruses targeting bacteria, have potential therapeutic applications in the control of infections with antibiotic-resistant bacteria. In this study, an Enterobacter cloacae phage, Ec_L1, was isolated from sewage sludge samples collected from a hospital. The genome of phage Ec_L1 consists of 51,894 bp with 48.24% G+C content. Nineteen of the 85 putative proteins encoded by this phage have known functions, and no rRNA or tRNA genes were found. Comparative analysis of genome sequences suggested that phage Ec_L1 should be considered a member of the subfamily Tunavirinae, which includes T1-like phages. According to the International Committee on Taxonomy of Viruses (ICTV), phage Ec_L1 is the type member of the new genus “Eclunavirus”, whose name was derived from Ec_L1.



中文翻译:

新型的阴沟肠杆菌噬菌体Ec_L1的基因组序列分析,该基因属于埃科鲁尼亚病毒属。

噬菌体是针对细菌的病毒,在控制抗生素抗性细菌的感染方面具有潜在的治疗应用。在这项研究中,从医院收集的污水污泥样本中分离出了阴沟肠杆菌噬菌体Ec_L1。噬菌体Ec_L1的基因组由51,894 bp组成,G + C含量为48.24%。该噬菌体编码的85种推定蛋白中有19种具有已知功能,没有发现rRNA或tRNA基因。基因组序列的比较分析表明,噬菌体Ec_L1应该被视为Tunavirinae亚家族的成员,该家族包括T1样噬菌体。根据国际病毒分类学委员会(ICTV)的研究,噬菌体Ec_L1是“埃克卢病毒”这一新属的类型成员。”,其名称源自Ec_L1。

更新日期:2020-06-08
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