The extracts and the compounds isolated from Phyllanthus amarus Schumm and Thonn (Family: Euphorbiaceae) have shown a wide spectrum of pharmacological activities including antiviral, antibacterial, antiplasmodial, antimalarial, antimicrobial, anticancer, antidiabetic, hypolipidemic, antioxidant, hepatoprotective, nephroprotective and diurectic properties.

Background: This investigation was aimed at exploring the anxiolytic potential of Phyllanthus amarus standardized extracts and predict probable role of marker phyto constitutents.

Objective and Methods: Three standardized extracts of Phyllanthus amarus plant viz. standardized aqueous extract of Phyllanthus amarus whole plant (PAAE), standardized methanolic extract of P. amarus leaf (PAME) and the standardized hydro-methanolic extract of P. amarus leaf (PAHME) were tested in the classical animal models of anxiety: Elevated plus-maze model and Light & Dark Exploration test.

Results: The lower doses of the tannin rich extract (PAHME) of the P. amarus possess significant anxiolytic activity compared to lignin rich (PAME) and aqueous extracts (PAAE), while at a higher dose (400mg/kg) the results of all three extracts appears to be potentially sedative. While the molecular docking studies support these probable anxiolytic, the sedative effects of the Phyllanthus amarus extracts could be due to the interaction of tannins and lignans with the GABAbenzodiazepine receptor complex.

Conclusion: The results of the present study indicate that the tannin-rich extract of the P. amarus may have potential clinical applications in the management of anxiety. It can be further studied for optimum dosage to be used as a future of anti-anxiety drug development or as a standardized Phytomedicine.

从 Phyllanthus amarus Schumm 和 Thonn（科：大戟科）中分离的提取物和化合物显示出广泛的药理活性，包括抗病毒、抗菌、抗疟原虫、抗疟、抗微生物、抗癌、抗糖尿病、降血脂、抗氧化、保肝、保护肾和利尿特性.

背景：本研究旨在探索 Phyllanthus amarus 标准化提取物的抗焦虑潜力，并预测标记植物成分的可能作用。

目的和方法：三种标准化的余甘子植物提取物即。在经典的焦虑动物模型中测试了 Phyllanthus amarus 全植物 (PAAE) 的标准化水提取物、P. amarus 叶的标准化甲醇提取物 (PAME) 和 P. amarus 叶的标准化氢甲醇提取物 (PAHME)： -迷宫模型和明暗探索测试。

结果：与富含木质素 (PAME) 和水提取物 (PAAE) 相比，低剂量的 P. amarus 富含单宁提取物 (PAHME) 具有显着的抗焦虑活性，而在较高剂量 (400mg/kg) 下，所有三种提取物似乎具有镇静作用。虽然分子对接研究支持这些可能的抗焦虑药，但 Phyllanthus amarus 提取物的镇静作用可能是由于单宁和木脂素与 GABA 苯二氮卓受体复合物的相互作用。

结论：本研究的结果表明，富含单宁的 P. amarus 提取物可能在治疗焦虑症方面具有潜在的临床应用。可以进一步研究最佳剂量，以用作抗焦虑药物开发的未来或作为标准化的植物医学。