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Co-effects of C/Ag dual ion implantation on enhancing antibacterial ability and biocompatibility of silicone rubber.
Biomedical Materials ( IF 4 ) Pub Date : 2020-09-25 , DOI: 10.1088/1748-605x/ab99d3 Xuan Zhou 1, 2 , Xin Zhou 1, 2 , Rongshuai Yan 1 , Xiaohua Shi 1 , Yichen Du 1 , Yao Chen 1 , Yao Yu 1 , Dongli Fan 1 , Yiming Zhang 1, 3
Biomedical Materials ( IF 4 ) Pub Date : 2020-09-25 , DOI: 10.1088/1748-605x/ab99d3 Xuan Zhou 1, 2 , Xin Zhou 1, 2 , Rongshuai Yan 1 , Xiaohua Shi 1 , Yichen Du 1 , Yao Chen 1 , Yao Yu 1 , Dongli Fan 1 , Yiming Zhang 1, 3
Affiliation
Although silicone implants are the most popular choice around the world for breast augmentation, reconstruction, and revision, due to the poor antibacterial properties and limited biocompatibility of silicone rubber (SR), one of the major complications, capsule contracture, is a lingering problem. To overcome the two main shortcomings, a dual ion implantation technique was applied to modify the surface of SR with the basic skeleton element of organic matter, carbon (C) and the broad-spectrum bactericide, silver (Ag). We present surface characterization, toxicological effects, and evaluation of the mechanical, antibacterial and biocompatible properties of C and Ag co-implanted SR (C/Ag−SRs). After ion implantation, surface roughness and tensile strength of these new materials increased. Biotoxicity was fully assessed by in vitro experiments on human fibroblasts and in vivo experiments on rats, showing that the low-Ag groups met safety standards. Both the anti-bacter...
中文翻译:
C/Ag双离子注入对增强硅橡胶抗菌能力和生物相容性的协同作用。
尽管硅胶植入物是世界上最受欢迎的隆胸、重建和翻修选择,但由于硅橡胶 (SR) 的抗菌性能差和生物相容性有限,主要并发症之一——包膜挛缩是一个挥之不去的问题。为了克服这两个主要缺点,采用双离子注入技术用有机物基本骨架元素碳 (C) 和广谱杀菌剂银 (Ag) 修饰 SR 的表面。我们介绍了 C 和 Ag 共植入 SR (C/Ag-SRs) 的表面表征、毒理学效应以及机械、抗菌和生物相容性的评估。离子注入后,这些新材料的表面粗糙度和抗拉强度增加。通过对人成纤维细胞的体外实验和对大鼠的体内实验对生物毒性进行了充分评估,表明低Ag组符合安全标准。无论是抗菌...
更新日期:2020-09-26
中文翻译:
C/Ag双离子注入对增强硅橡胶抗菌能力和生物相容性的协同作用。
尽管硅胶植入物是世界上最受欢迎的隆胸、重建和翻修选择,但由于硅橡胶 (SR) 的抗菌性能差和生物相容性有限,主要并发症之一——包膜挛缩是一个挥之不去的问题。为了克服这两个主要缺点,采用双离子注入技术用有机物基本骨架元素碳 (C) 和广谱杀菌剂银 (Ag) 修饰 SR 的表面。我们介绍了 C 和 Ag 共植入 SR (C/Ag-SRs) 的表面表征、毒理学效应以及机械、抗菌和生物相容性的评估。离子注入后,这些新材料的表面粗糙度和抗拉强度增加。通过对人成纤维细胞的体外实验和对大鼠的体内实验对生物毒性进行了充分评估,表明低Ag组符合安全标准。无论是抗菌...